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首页> 外文期刊>Analytica chimica acta >Boronic acid-decorated metal-organic frameworks modified via a mixed-ligand strategy for the selective enrichment of cis-diol containing nucleosides
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Boronic acid-decorated metal-organic frameworks modified via a mixed-ligand strategy for the selective enrichment of cis-diol containing nucleosides

机译：通过混合配体策略改性硼酸装饰金属 - 有机框架，用于选择性富集含有核苷的CIS-DIOL

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摘要

Functional metal-organic frameworks (MOFs) constructed via a pre-installation strategy of introducing mixed organic ligands have attracted considerable interest in various fields. In the present study, boronic acid decorated magnetic Zr-MOFs were successfully synthesized by introducing 3-carboxyphenylboronic acid ligands as fragments. The prepared material was used as an adsorbent for the enrichment of cis-diolcontaining nucleosides. The adsorbent has excellent performance with regard to the enrichment and separation of the nucleosides. This may be attributed to its abundant boronic acid functional groups, and the convenience of magnetic separation it provides. The obtained material was chemically stable over a large pH range. The degree of linearity of the nucleosides was excellent (0.02-10 mu g mL(-1)), and the detection and quantification limits were low (0.006-0.016 mu g mL(-1) and 0.02-0.05 mu g mL(-1), respectively). Furthermore, it was possible to attain adsorption equilibrium within 10 min. The high efficiency of this method makes it suitable for the successful extraction of nucleosides from human urine samples, with satisfactory recoveries of 88-146%, and 1.7-9.4% precision. We believe that the fabricated functional magnetic MOFs have great potential for the analysis of other cis-diol-containing target, and the pre-installation strategy could be adapted for the wider application of MOFs. (C) 2020 Elsevier B.V. All rights reserved.
机译：通过预安装策略引入混合有机配体的预安装策略的功能金属 - 有机框架（MOF）吸引了各种领域的相当兴趣。在本研究中，通过将3-羧基苯磺酰芳烃配体作为片段将3-羧基苯硼酸配体成功地合成了硼酸装饰磁性ZR-MOF。制备的材料用作富集Cis-二硅核苷的吸附剂。关于核苷的富集和分离，吸附剂具有出色的性能。这可能归因于其丰富的硼酸官能团，以及它提供的磁性分离的便利性。所得材料在大的pH范围内进行化学稳定。核苷的线性度优异（0.02-10μgml（-1）），检测和定量限制低（0.006-0.016μgml（-1）和0.02-0.05μg（ - 1）分别）。此外，可以在10分钟内获得吸附平衡。该方法的高效率使其适用于从人尿液中成功提取核苷，令人满意的回收率为88-146％，精度为1.7-9.4％。我们认为，制造的功能性磁性MOF对含CIS-DIOL的目标的分析具有很大的潜力，并且可以适用于更广泛地应用MOF的安装策略。 （c）2020 Elsevier B.V.保留所有权利。

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