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首页> 外文期刊>Advanced Functional Materials >Near-Infrared Triggered Release of uPA from Nanospheres for Localized Hyperthermia-Enhanced Thrombolysis
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Near-Infrared Triggered Release of uPA from Nanospheres for Localized Hyperthermia-Enhanced Thrombolysis

机译：uPA从纳米球的近红外触发释放，用于局部热疗增强型溶栓

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摘要

Currently, most thrombolytic agents are limited by short circulation time and excessive dose needed for clinical therapy, which increases lethal risk for intracranial hemorrhage. Here, a near-infrared-triggered, controlled-release system, using gold@mesoporous silica core-shell nanospheres (Au@MSNs) with phase-changed material 1-tetradecanol, is formulated to release urokinase plasminogen activators (uPA) on demand. The prepared system presents a sensitive system for releasing uPA, owing to an elevated temperature created by Au@MSNs-induced photothermal effect. For in vitro study, a 3D printed vein vasculature is designed and fabricated to simulate the thrombolysis of system in blood vessel. Murine tail thrombus model is also built to evaluate thrombolysis in vivo. Consequently, localized hyperthermia is validated to possess an effective enhancement for thrombolysis. Therefore, according to the results, the fabricated system demonstrates two aspects of potential superiority: controlled uPA release for reducing risk of side effects, and hyperthermia-enhanced thrombolysis locally for decreasing drug dosage. Assisted with thermal thrombolysis, the present formulated system shows a high efficiency, on-demand drug release, and thus a safer protocol for thrombolytic therapy, which fits the developing trends of precision medicine.
机译：当前，大多数溶栓剂受到循环时间短和临床治疗所需剂量过多的限制，这增加了颅内出血的致死风险。在这里，配制了一种近红外触发的控释系统，该系统使用具有相变材料1-十四癸醇的金@介孔二氧化硅核-壳纳米球（Au @ MSNs），可按需释放尿激酶纤溶酶原激活剂（uPA）。由于Au @ MSNs诱导的光热效应导致温度升高，所制备的系统具有释放uPA的灵敏系统。对于体外研究，设计并制造了3D打印的静脉血管系统，以模拟血管系统的溶栓作用。还建立了鼠尾部血栓模型来评估体内溶栓。因此，证实局部热疗对溶栓具有有效的增强作用。因此，根据结果，所制造的系统显示出两个方面的潜在优势：受控的uPA释放可降低副作用的风险，局部热疗增强的溶栓作用可降低药物剂量。在热溶栓作用的辅助下，本配方系统显示出高效率，按需释放药物，因此是一种更安全的溶栓治疗方案，符合精密医学的发展趋势。

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  • 来源
    《Advanced Functional Materials》 |2017年第40期|1701824.1-1701824.8|共8页
  • 作者

    Wang Xiaolei; Wei Chaochao; Liu Mengke; Yang Ting; Zhou Weimin; Liu Ying; Hong Kui; Wang Shuhua; Xin Hongbo; Ding Xingwei;

  • 作者单位

    Nanchang Univ, Inst Translat Med, Nanchang 330088, Jiangxi, Peoples R China;

    Nanchang Univ, Inst Translat Med, Nanchang 330088, Jiangxi, Peoples R China;

    Nanchang Univ, Inst Translat Med, Nanchang 330088, Jiangxi, Peoples R China;

    Nanchang Univ, Inst Translat Med, Nanchang 330088, Jiangxi, Peoples R China;

    Nanchang Univ, Affiliated Hosp 2, Dept Vasc Surg, Nanchang 330006, Jiangxi, Peoples R China;

    Nanchang Univ, Sch Mech & Elect Engn, Nanchang 330031, Jiangxi, Peoples R China;

    Nanchang Univ, Affiliated Hosp 2, Dept Cardiovasc Med, Nanchang 330006, Jiangxi, Peoples R China;

    Nanchang Univ, Dept Chem, Nanchang 330031, Jiangxi, Peoples R China;

    Nanchang Univ, Inst Translat Med, Nanchang 330088, Jiangxi, Peoples R China;

    Nanchang Univ, Inst Translat Med, Nanchang 330088, Jiangxi, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    controlled release; drug delivery; hyperthermal thrombolysis; photothermal therapy; thromboembolism;

    机译：控释;药物输送;高热溶栓;光热疗法;血栓栓塞;

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