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首页> 外文期刊>Advanced Functional Materials >Assessment of Novel Long-Lasting Ceria-Stabilized Zirconia-Based Ceramics with Different Surface Topographies as Implant Materials
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Assessment of Novel Long-Lasting Ceria-Stabilized Zirconia-Based Ceramics with Different Surface Topographies as Implant Materials

机译：具有不同表面形貌作为植入材料的新型长寿命二氧化铈稳定的氧化锆基陶瓷的评估

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摘要

The development of long-lasting zirconia-based ceramics for implants, which are not prone to hydrothermal aging, is not satisfactorily solved. Therefore, this study is conceived as an overall evaluation screening of novel ceria-stabilized zirconia-alumina-aluminate composite ceramics (ZA(8)Sr(8)-Ce11) with different surface topographies for use in clinical applications. Ceria-stabilized zirconia is chosen as the matrix for the composite material, due to its lower susceptibility to aging than yttria-stabilized zirconia (3Y-TZP). This assessment is carried out on three preclinical investigation levels, indicating an overall biocompatibility of ceria-stabilized zirconia-based ceramics, both in vitro and in vivo. Long-term attachment and mineralized extracellular matrix (ECM) deposition of primary osteoblasts are the most distinct on porous ZA(8)Sr(8)-Ce11(p) surfaces, while ECM attachment on 3Y-TZP and ZA(8)Sr(8)-Ce11 with compact surface texture is poor. In this regard, the animal study confirms the porous ZA(8)Sr(8)-Ce11(p) to be the most favorable material, showing the highest bone-to-implant contact values and implant stability post implantation in comparison with control groups. Moreover, the microbiological evaluation reveals no favoritism of biofilm formation on the porous ZA(8)Sr(8)-Ce11(p) when compared to a smooth control surface. Hence, together with the in vitro in vivo assessment analogy, the promising clinical potential of this novel ZA(8)Sr(8)-Ce11 as an implant material is demonstrated.
机译：不能令人满意地解决开发不易发生水热老化的用于植入物的长效氧化锆基陶瓷的问题。因此，本研究被认为是具有不同表面形貌的新型二氧化铈稳定的氧化锆-氧化铝-铝酸盐复合陶瓷（ZA（8）Sr（8）-Ce11）的整体评估筛选，可用于临床应用。选择氧化铈稳定的氧化锆作为复合材料的基质，因为它比氧化钇稳定的氧化锆（3Y-TZP）的老化敏感性低。该评估是在三个临床前研究水平上进行的，表明在体外和体内，二氧化铈稳定的氧化锆基陶瓷的总体生物相容性。主要的成骨细胞的长期附着和矿化的细胞外基质（ECM）沉积在多孔ZA（8）Sr（8）-Ce11（p）表面上最明显，而ECM在3Y-TZP和ZA（8）Sr（ 8）-具有致密表面纹理的Ce11较差。在这方面，动物研究证实多孔ZA（8）Sr（8）-Ce11（p）是最有利的材料，与对照组相比，植入后的骨与植入物接触值和植入物稳定性最高。 。此外，微生物评估表明，与光滑的对照表面相比，多孔ZA（8）Sr（8）-Ce11（p）上没有生物膜形成的偏爱。因此，与体外体内评估类比，证明了这种新颖的ZA（8）Sr（8）-Ce11作为植入材料的有希望的临床潜力。

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  • 来源
    《Advanced Functional Materials》 |2017年第40期|1702512.1-1702512.14|共14页
  • 作者

    Altmann Brigitte; Karygianni Lamprini; Al-Ahmad Ali; Butz Frank; Baechle Maria; Adolfsson Erik; Fuerderer Tobias; Courtois Nicolas; Palmero Paola; Follo Marie; Chevalier Jerome; Steinberg Thorsten; Kohal Ralf Joachim;

  • 作者单位

    Univ Freiburg, Fac Med, Med Ctr, Dept Prosthet Dent, Hugstetter Str 55, D-79106 Freiburg, Germany|Univ Freiburg, Fac Med, Med Ctr, Dept Oral & Maxillofacial Surg,GERN Tissue Replac, Hugstetter Str 55, D-79106 Freiburg, Germany;

    Univ Freiburg, Fac Med, Med Ctr, Dept Operat Dent & Periodontol, Hugstetter Str 55, D-79106 Freiburg, Germany|Univ Zurich, Ctr Dent Med, Clin Prevent Dent Periodontol & Cariol, Plattenstr 11, CH-8032 Zurich, Switzerland;

    Univ Freiburg, Fac Med, Med Ctr, Dept Operat Dent & Periodontol, Hugstetter Str 55, D-79106 Freiburg, Germany;

    Univ Freiburg, Fac Med, Med Ctr, Dept Prosthet Dent, Hugstetter Str 55, D-79106 Freiburg, Germany;

    Univ Freiburg, Fac Med, Med Ctr, Dept Prosthet Dent, Hugstetter Str 55, D-79106 Freiburg, Germany;

    Swerea IVF AB, Argongatan 30, S-43153 Molndal, Sweden;

    MOESCHTER Grp Holding GmbH & Co KG, Hesslingsweg 65 67, D-44309 Dortmund, Germany;

    ANTHOGYR R&D, 2237 Ave A Lasquin, F-74700 Sallanches, France;

    Politecn Torino, INSTM RU PoliTO, LINCE Lab, Dept Appl Sci & Technol, Corso Duca Abruzzi 24, I-10129 Turin, Italy;

    Univ Freiburg, Fac Med, Med Ctr, Dept Med 1, Hugstetter Str 55, D-79106 Freiburg, Germany;

    Univ Lyon, MATEIS UMR CNRS 5510, INSA Lyon, Bat Blaise Pascal 7,Av Jean Capelle, F-69621 Villeurbanne, France;

    Univ Freiburg, Fac Med, Med Ctr, Dept Oral Biotechnol,Ctr Dent Med, Hugstetter Str 55, D-79106 Freiburg, Germany;

    Univ Freiburg, Fac Med, Med Ctr, Dept Prosthet Dent, Hugstetter Str 55, D-79106 Freiburg, Germany;

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  • 正文语种 eng
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  • 关键词

    bacterial adhesion; human osteoblasts; implant materials; osseointegration; zirconia-based composites;

    机译：细菌粘附;人类成骨细胞;植入材料;骨整合;氧化锆基复合材料;

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