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首页> 外文期刊>Advanced Functional Materials >Folic-Acid-Mediated Functionalized Gold Nanocages for Targeted Delivery of Anti-miR-181b in Combination of Gene Therapy and Photothermal Therapy against Hepatocellular Carcinoma
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Folic-Acid-Mediated Functionalized Gold Nanocages for Targeted Delivery of Anti-miR-181b in Combination of Gene Therapy and Photothermal Therapy against Hepatocellular Carcinoma

机译：叶酸介导的功能化金纳米笼，针对基因表达和光热疗法联合靶向抗miR-181b肝细胞癌。

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摘要

Therapeutic strategies based on modulation of microRNAs (miRNAs) activity hold much promise for cancer therapy, but for clinical applications, the efficient delivery of miRNAs to tumor cells or tumor tissues remains a great challenge. In this work, microRNA-181b inhibitor (anti-miR-181b) is successfully condensed into polyethyleneimine (PEI)-modified and folate receptor (FR)-targeted PEGylated gold nanocages (AuNCs). This delivery system is designated as anti-miR-181b/PTPAuNCs nanocomplexes (PTPAuNC-NPs), which begin with chemical modification of AuNCs with SH-PEG(5000)-folic acid (SH-PEG(5000)-FA) and SH-PEG(5000) through a gold-sulfur bond, followed by conjugating PEI using lipoic acid as a linker. Finally anti-miR-181b is condensed via electrostatic interactions. In vitro and in vivo experiments show that PTPAuNC-NPs can efficiently deliver anti-miR-181b into target sites to suppress tumor growth, and considerably decrease tumor volumes in SMMC-7721 tumor-bearing nude mice under near-infrared radiation. All these results suggest that PTPAuNC-NP gene delivery system with combination of gene therapy and photothermal therapy will be of great potential use in future cancer therapy.
机译：基于微RNA（miRNA）活性调节的治疗策略在癌症治疗中具有广阔的前景，但对于临床应用而言，将miRNA有效递送至肿瘤细胞或肿瘤组织仍然是巨大的挑战。在这项工作中，microRNA-181b抑制剂（抗miR-181b）成​​功地缩合到聚乙烯亚胺（PEI）修饰和叶酸受体（FR）靶向的聚乙二醇化金纳米笼（AuNCs）中。该递送系统被称为抗miR-181b / PTPAuNCs纳米复合物（PTPAuNC-NPs），其始于用SH-PEG（5000）-叶酸（SH-PEG（5000）-FA）和SH-通过金-硫键形成PEG（5000），然后使用硫辛酸作为接头缀合PEI。最终，抗miR-181b通过静电相互作用凝聚。体外和体内实验表明，PTPAuNC-NP可以有效地将抗miR-181b传递到靶位点以抑制肿瘤生长，并显着减少SMMC-7721荷瘤裸鼠在近红外辐射下的肿瘤体积。所有这些结果表明，结合了基因疗法和光热疗法的PTPAuNC-NP基因递送系统将在未来的癌症疗法中具有巨大的潜在用途。

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  • 来源
    《Advanced Functional Materials》 |2016年第15期|2532-2544|共13页
  • 作者

    Huang Shengnan; Duan Shaofeng; Wang Jing; Bao Shijin; Qiu Xiaojing; Li Chunming; Liu Ying; Yan Lijuan; Zhang Zhenzhong; Hu Yurong;

  • 作者单位

    Zhengzhou Univ, Sch Pharmaceut Sci, 100 Kexue Ave, Zhengzhou 450001, Peoples R China;

    Zhengzhou Univ, Affiliated Hosp 1, 1 Construction Rd, Zhenzhong 450052, Peoples R China;

    Zhengzhou Univ, Sch Pharmaceut Sci, 100 Kexue Ave, Zhengzhou 450001, Peoples R China|Yanzhou Peoples Hosp, Dept Pharm, 99 Jianshe Xi Rd, Jining 272100, Peoples R China;

    Zhengzhou Univ, Sch Pharmaceut Sci, 100 Kexue Ave, Zhengzhou 450001, Peoples R China;

    Zhengzhou Univ, Sch Pharmaceut Sci, 100 Kexue Ave, Zhengzhou 450001, Peoples R China;

    Zhengzhou Univ, Sch Pharmaceut Sci, 100 Kexue Ave, Zhengzhou 450001, Peoples R China;

    Zhengzhou Univ, Sch Pharmaceut Sci, 100 Kexue Ave, Zhengzhou 450001, Peoples R China;

    Zhengzhou Univ, Sch Pharmaceut Sci, 100 Kexue Ave, Zhengzhou 450001, Peoples R China;

    Zhengzhou Univ, Sch Pharmaceut Sci, 100 Kexue Ave, Zhengzhou 450001, Peoples R China|Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450001, Henan Province, Peoples R China;

    Zhengzhou Univ, Sch Pharmaceut Sci, 100 Kexue Ave, Zhengzhou 450001, Peoples R China|Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou 450001, Henan Province, Peoples R China|Zhengzhou Univ, Acad Med Sci, Zhengzhou 450052, Peoples R China;

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