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首页> 外文期刊>Advanced Functional Materials >Unprecedented 'All-in-One' Lanthanide-Doped Mesoporous Silica Frameworks for Fluorescence/MR Imaging and Combination of NIR Light Triggered Chemo-Photodynamic Therapy of Tumors
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Unprecedented 'All-in-One' Lanthanide-Doped Mesoporous Silica Frameworks for Fluorescence/MR Imaging and Combination of NIR Light Triggered Chemo-Photodynamic Therapy of Tumors

机译：前所未有的“多合一”掺杂镧系元素的介孔二氧化硅骨架用于荧光/ MR成像和近红外光触发的肿瘤化学光动力疗法的组合

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Designing a single multifunctional nanoparticle that can simultaneously impart both diagnostic and therapeutic functions is considered to be a long-lasting hurdle for biomedical researchers. Conventionally, a multifunctional nanoparticle can be constructed by integrating organic dyes/magnetic nanoparticles to impart diagnostic functions and anticancer drugs/photosensitizers to achieve therapeutic outcomes. These multicomponents systems usually suffer from severe photobleaching problems and cannot be activated by near-infrared (NIR) light. Here, it is demonstrated that all-in-one lanthanide-doped mesoporous silica frameworks (EuGdOx@MSF) loaded with an anticancer drug, doxorubicin (DOX) can facilitate simultaneous bimodal magnetic resonance (MR) imaging with approximately twofold higher T1-MR contrast as compared to the commercial Gd(III)-DTPA complex and fluorescence imaging with excellent photostability. Upon a very low dose (130 mW cm(-2)) of NIR light (980 nm) irradiation, the EuGdOx@MSF not only can sensitize formation of singlet oxygen (O-1(2)) by itself but also can phototrigger the release of the DOX payload effectively to exert combined chemo-photodynamic therapeutic (PDT) effects and destroy solid tumors in mice completely. It is also discovered for the first time that the EuGdOx@MSF-mediated PDT effect can suppress the level of the key drug resistant protein, i.e., p-glycoprotein (p-gp) and help alleviate the drug resistant problem commonly associated with many cancers.
机译：设计一种可以同时赋予诊断和治疗功能的多功能纳米颗粒被认为是生物医学研究人员的长期障碍。常规地，可以通过整合有机染料/磁性纳米颗粒以赋予诊断功能和抗癌药物/光敏剂以实现治疗效果来构建多功能纳米颗粒。这些多组分系统通常遭受严重的光致漂白问题，并且不能被近红外（NIR）光激活。在这里，已证明，负载有抗癌药阿霉素（DOX）的多掺杂镧系元素掺杂的中孔二氧化硅骨架（EuGdOx @ MSF）可以促进同时双峰磁共振（MR）成像，且T1-MR对比度高约两倍与商用Gd（III）-DTPA复合物和具有出色光稳定性的荧光成像相比。在非常低的剂量（130 mW cm（-2））的NIR光（980 nm）照射下，EuGdOx @ MSF不仅可以自身敏化单线态氧（O-1（2））的形成，而且还可以触发光。释放DOX有效负载可有效发挥化学光动力治疗（PDT）的综合作用，并完全破坏小鼠体内的实体瘤。还首次发现EuGdOx @ MSF介导的PDT效应可以抑制关键的耐药蛋白即p-糖蛋白（p-gp）的水平，并有助于减轻通常与许多癌症相关的耐药性问题。

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