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Porous Silicon Nanodiscs for Targeted Drug Delivery

机译：多孔硅纳米盘用于靶向药物输送

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摘要

There is a strong demand for techniques that allow the fabrication of bio-compatible porous nanoparticles for drug delivery applications. In this work, a new method to fabricate size- and shape-controlled porous silicon (pSi) nanodiscs is described. The process relies on a combination of colloidal lithography and metal-assisted chemical etching. Height and diameter of the pSi nanodiscs can be easily adjusted. The nanodiscs are degradable in physiological milieu and are nontoxic to mammalian cells. In order to highlight the potential of the pSi nanodiscs in drug delivery, an in vitro investigation that involved loading of nanodiscs with the anticancer agent camptothecin and functionalization of the nanodisc periphery with an antibody that targets receptors on the surface of neuroblastoma cells is carried out. The thus-prepared nanocarriers are found to selectively attach to and kill cancer cells.
机译：对允许制造用于药物递送应用的生物相容性多孔纳米颗粒的技术存在强烈需求。在这项工作中，描述了一种制造尺寸和形状受控的多孔硅（pSi）纳米圆盘的新方法。该工艺依赖于胶体光刻和金属辅助化学蚀刻的结合。 pSi纳米光盘的高度和直径可以轻松调整。纳米盘可在生理环境中降解，并且对哺乳动物细胞无毒。为了突出pSi纳米光盘在药物输送中的潜力，进行了一项体外研究，该研究涉及将抗癌剂喜树碱装载到纳米光盘中，并使用靶向成神经细胞瘤细胞表面受体的抗体对纳米光盘外围进行功能化。发现由此制备的纳米载体选择性地附着并杀死癌细胞。

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  • 来源
    《Advanced Functional Materials》 |2015年第7期|1137-1145|共9页
  • 作者

    Hashim Alhmoud; Bahman Delalat; Roey Elnathan; Anna Cifuentes-Rius; Arnaud Chaix; Mary-Louise Rogers; Jean-Olivier Durand; Nicolas H. Voelcker;

  • 作者单位

    Mawson Institute University of South Australia Mawson Lakes SA 5095, Australia;

    Mawson Institute University of South Australia Mawson Lakes SA 5095, Australia;

    Mawson Institute University of South Australia Mawson Lakes SA 5095, Australia;

    Mawson Institute University of South Australia Mawson Lakes SA 5095, Australia;

    Institut Charles Gerhardt Montpellier (ICGM) Universite Montpellier 2 34095, Montpellier, France;

    Department of Human Physiology Centre for Neuroscience Flinders University Bedford Park, SA 5042, Australia;

    Institut Charles Gerhardt Montpellier (ICGM) Universite Montpellier 2 34095, Montpellier, France;

    Mawson Institute University of South Australia Mawson Lakes SA 5095, Australia;

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