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首页> 外文期刊>Advanced Functional Materials >Photostable lodinated Silica/Porphyrin Hybrid Nanoparticles with Heavy-Atom Effect for Wide-Field Photodynamic/ Photothermal Therapy Using Single Light Source
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Photostable lodinated Silica/Porphyrin Hybrid Nanoparticles with Heavy-Atom Effect for Wide-Field Photodynamic/ Photothermal Therapy Using Single Light Source

机译：具有重原子效应的光稳定卤化二氧化硅/卟啉杂化纳米颗粒，可用于单光源的宽域光动力/光热疗法

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摘要

Physical therapies including photodynamic therapy (PDT) and photo-thermal therapy (PTT) can be effective against diseases that are resistant to chemotherapy and remain as incurable malignancies (for example, multiple myeloma). In this study, to enhance the treatment efficacy for multiple myeloma using the synergetic effect brought about by combining PDT and PTT, iodinated silica/porphyrin hybrid nanopartides (ISP HNPs) with high photostability are developed. They can generate both ~1O_2 and heat with irradiation from a light-emitting diode (LED), acting as photosensitizers for PDT/ PTT combination treatment. ISP HNPs exhibit the external heavy atom effect, which significantly improves both the quantum yield for ~1O_2 generation and the light-to-heat conversion efficiency. The in vivo fluorescence imaging demonstrates that ISP HNPs, modified with folic acid and polyethylene glycol (FA-PEC-ISP HNPs), locally accumulate in the tumor after 18 h of their intravenous injection into tumor-bearing mice. The LED irradiation on the tumor area of the mice injected with FA-PEC-ISP HNPs causes necrosis of the tumor tissues, resulting in the inhibition of tumor growth and an improvement in the survival rate.
机译：包括光动力疗法（PDT）和光热疗法（PTT）在内的物理疗法可以有效抵抗那些对化疗具有抗药性且仍可治愈的恶性肿瘤（例如多发性骨髓瘤）。在这项研究中，为了利用PDT和PTT结合产生的协同效应提高多发性骨髓瘤的治疗效果，开发了具有高光稳定性的碘化二氧化硅/卟啉杂化纳米颗粒（ISP HNP）。在发光二极管（LED）的照射下，它们可以产生〜1O_2和热量，用作PDT / PTT组合治疗的光敏剂。 ISP HNP具有外部重原子效应，可显着提高〜1O_2生成的量子产率和光热转换效率。体内荧光成像表明，经叶酸和聚乙二醇修饰的ISP HNP（FA-PEC-ISP HNP）在向荷瘤小鼠静脉注射18小时后，在肿瘤中局部蓄积。用FA-PEC-ISP HNPs注射的小鼠的肿瘤区域受到LED照射会导致肿瘤组织坏死，从而抑制肿瘤生长并提高存活率。

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  • 来源
    《Advanced Functional Materials》 |2014年第4期|503-513|共11页
  • 作者

    Koichiro Hayashi; Michihiro Nakamura; Hirokazu Miki; Shuji Ozaki; Masahiro Abe; Toshio Matsumoto; Toshinari Kori; Kazunori Ishimura;

  • 作者单位

    Department of Anatomy and Cell Biology Institute of Health Biosciences The University of Tokushima Graduate School 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan;

    Department of Anatomy and Cell Biology Institute of Health Biosciences The University of Tokushima Graduate School 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan;

    Division of Transfusion Medicine Tokushima University Hospital 2-50-1 Kuramoto-cho, Tokushima, 770-0042, Japan;

    Department of Internal Medicine Tokushima Prefectural Central Hospital 1-10-3 Kuramoto-cho, Tokushima, 770-0042, Japan;

    Department of Medicine and Bioregulatory Sciences The University of Tokushima Graduate School of Medical Sciences 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan;

    Department of Medicine and Bioregulatory Sciences The University of Tokushima Graduate School of Medical Sciences 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan;

    Tokushima Prefectural Industrial Technology Center 11-2 Nishibari, Saigacho, Tokushima, 770-8021, Japan;

    Department of Anatomy and Cell Biology Institute of Health Biosciences The University of Tokushima Graduate School 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan;

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