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首页> 外文期刊>Nanotechnology >Facile formulation of near-infrared light-triggered hollow mesoporous silica nanoparticles based on mitochondria targeting for on-demand chemo/photothermal/photodynamic therapy
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Facile formulation of near-infrared light-triggered hollow mesoporous silica nanoparticles based on mitochondria targeting for on-demand chemo/photothermal/photodynamic therapy

机译：基于线粒体靶向靶向靶向的近红外光触发中空介孔二氧化硅靶线靶向按需化学/光热/光动力学治疗

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摘要

The incorporation of chemo/photothermal/photodynamic therapy in subcellular organelles such as mitochondria has attracted extensive attention recently. Here, we designed mitochondria-targeted hollow mesoporous silica nanoparticles (THMSNs) loaded biocompatible phase-change material L-menthol (LM) via a facile method. Meanwhile, antitumor drug doxorubicin (DOX) and near-infrared (NIR) dye indocyanine green (ICG) approved by FDA were simultaneously encapsulated into THMSNs, denoted as THMSNs@LMDI, which showed NIR radiation triggered capacity for cancer treatment. With the mitochondria-targeted ability of triphenylphosphine, the resulting THMSNs@LMDI showed evidently improved cellular internalization and specific accumulation in mitochondria. Under NIR irradiation, the versatile ICG would be bound to simultaneously produce photodynamic and photothermal therapy. Meanwhile, in view of the solid-liquid phase transition feature of gatekeeper LM, THMSNs@LMDI provided a platform for NIR-mediated temperature-responsive DOX release. As a matter of course, these smart subcellular organelle-THMSNs could serve as an effective drug delivery platform for site-specific on-demand chemo/photothermal/photodynamic therapy of cancer.
机译：在亚细胞细胞细胞中的化疗/光热/光动力学疗法掺入Mitochondria的亚细胞细胞器中最近引起了广泛的关注。这里，我们通过容易方法设计了线粒体靶向中空介孔二氧化硅纳米颗粒（THMSNS）的生物相容性相变材料L-薄荷醇（LM）。同时，通过FDA批准的抗肿瘤药物多柔比星（DOX）和近红外（NIR）染料吲哚菁绿（ICG）同时包封成THMSNS，表示为LMDI的ZMSNS，显示出尿辐射触发癌症治疗能力。随着三苯基膦的线粒体靶向能力，所得THMSNS @ LMDI显示出明显改善了线粒体中的细胞内化和特异性积累。在NIR辐射下，通用ICG将被束同时产生光动力和光热疗法。同时，鉴于Gatekeeper LM的固液相​​变特征，THMSNS @ LMDI为NIR介导的温度响应性DOX释放提供了平台。当然，这些智能亚细胞细胞器-THMSNS可以作为癌症特异性特定于需求的化疗/光热/光动力学治疗的有效药物递送平台。

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