• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Advanced Functional Materials >Free-Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues
【24h】

Free-Standing Cell Sheet Assembled with Ultrathin Extracellular Matrix as an Innovative Approach for Biomimetic Tissues

机译：独立式细胞片与超薄细胞外基质组装作为仿生组织的创新方法

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Current artificial tissue-substitutes have limited clinical applications due to unmatched complex combination of cells and extracellular matrix (ECM) as seen in native tissues. From a developmental perspective, the construction of effective biomimetic tissues is from the bottom (one-dimensional nano-particles or two-dimensional membranes) up (three-dimensional scaffolds or more complex composite). In a hierarchical architecture, each sub-structure can be assembled in a flexible way with specific regulators and cells, which overcomes the deficiency of one-for-all scaffold. Here, a cell-compatible cell-lined layered nano-membrane is developed. Bioactive molecules are mounted on a nano-membrane and later released to its lined cell sheet. The cell-lined membrane is in a free-standing form to regulate cellular functions. The major advantage of this methodology is to provide a versatile approach to construct biomimetic tissues for clinical applications.
机译：由于天然组织中细胞与细胞外基质（ECM）的复杂结合不匹配，当前的人工组织替代品在临床上的应用受到限制。从发展的角度来看，有效的仿生组织的构造是从底部（一维纳米颗粒或二维膜）向上（三维支架或更复杂的复合材料）开始的。在分层体系结构中，每个子结构都可以通过灵活的方式与特定的调节器和单元进行组装，从而克服了脚手架的缺点。在此，开发了细胞相容的细胞内衬层状纳米膜。将生物活性分子固定在纳米膜上，然后释放到其衬里的细胞片中。带细胞膜的膜呈独立形式，可调节细胞功能。该方法的主要优点是为构建用于临床应用的仿生组织提供了一种通用方法。

著录项

  • 来源
    《Advanced Functional Materials》 |2014年第15期|2216-2223|共8页
  • 作者

    Jun Chen; Xiaozhong Qiu; Leyu Wang; Wen Zhong; Jiming Kong; Malcolm M. Q. Xing;

  • 作者单位

    School of Basic Medical Science Southern Medical University Guangzhou 510515, China,Department of Mechanical and Manufacturing Engineering University of Manitoba Winnipeg, MB R3T 2N2, Canada,Manitoba Institute of Child Health 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada,CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Sciences Beijing 100049, China;

    School of Basic Medical Science Southern Medical University Guangzhou 510515, China;

    School of Basic Medical Science Southern Medical University Guangzhou 510515, China;

    School of Basic Medical Science Southern Medical University Guangzhou 510515, China,Department of Medical Microbiology Faculty of Medicine University of Manitoba Winnipeg, MB R3E 0J9, Canada;

    School of Basic Medical Science Southern Medical University Guangzhou 510515, China,Department of Human Anatomy and Cell Sciences Faculty of Medicine University of Manitoba Winnipeg, MB R3E 0J9, Canada;

    School of Basic Medical Science Southern Medical University Guangzhou 510515, China,Department of Mechanical and Manufacturing Engineering University of Manitoba Winnipeg, MB R3T 2N2, Canada,Manitoba Institute of Child Health 715 McDermot Avenue, Winnipeg, MB R3E 3P4, Canada,Department of Biochemistry and Medical Genetics University of Manitoba Winnipeg, MB R3E 0W3, Canada;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号