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Nanometric Micelles with Photo-Triggered Cytotoxicity

机译：光引发细胞毒性的纳米胶束

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摘要

The development of a photo-responsive micellar system capable of triggering cell death is reported. Precursors of the micelles are synthesized by connecting a lipophilic chain to a hydrophilic polyethylene glycol via a photo-labile nitrobenzyl group. The resulting amphiphilic units are self-assembled in water forming 12 nm micelles that are readily internalized into cells. Upon photo-irradiation, micelles undergo cleavage and yield a cytotoxic nitrosoben-zaldehyde derivative, which significantly inhibits the proliferation of MDAMB-231 cells under standard in vitro conditions.
机译：据报道，能够触发细胞死亡的光响应胶束系统的发展。胶束的前体是通过光不稳定的硝基苄基将亲脂性链与亲水性聚乙二醇连接而合成的。产生的两亲性单元在水中自组装，形成易于内化到细胞中的12 nm胶束。光照射后，胶束会裂解并产生细胞毒性的亚硝基苯甲醛衍生物，在标准的体外条件下，该衍生物会明显抑制MDAMB-231细胞的增殖。

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  • 来源
    《Advanced Functional Materials》 |2014年第33期|5246-5252|共7页
  • 作者

    Parambath Anilkumar; Edmond Gravel; Ioanna Theodorou; Karine Gombert; Benoit Theze; Frederic Duconge; Eric Doris;

  • 作者单位

    CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage 91191, Gif-sur-Yvette, France;

    CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage 91191, Gif-sur-Yvette, France;

    CEA, I~2BM, Molecular Imaging Research Center (MIRCen), 18 route du panorama, BP n°6 F-92265, Fontenay-aux-Roses, France,CNRS, Unite de Recherche Associee CEA-CNRS2210, 18 route du panorama, BP n°6 F-92265, Fontenay-aux-Roses, France,CEA, I~2BM, Service Hospitalier Frederic Joliot (SHFJ) 4 place du general Leclerc 91401, Orsay, France,INSERM U1023 Laboratoire d'Imagerie Moleculaire Experimentale 4 place du general Leclerc 91401, Orsay, France,Universite Paris Sud 4 place du general Leclerc 91401, Orsay, France;

    CEA, I~2BM, Service Hospitalier Frederic Joliot (SHFJ) 4 place du general Leclerc 91401, Orsay, France,INSERM U1023 Laboratoire d'Imagerie Moleculaire Experimentale 4 place du general Leclerc 91401, Orsay, France,Universite Paris Sud 4 place du general Leclerc 91401, Orsay, France;

    CEA, I~2BM, Service Hospitalier Frederic Joliot (SHFJ) 4 place du general Leclerc 91401, Orsay, France,INSERM U1023 Laboratoire d'Imagerie Moleculaire Experimentale 4 place du general Leclerc 91401, Orsay, France,Universite Paris Sud 4 place du general Leclerc 91401, Orsay, France;

    CEA, I~2BM, Molecular Imaging Research Center (MIRCen), 18 route du panorama, BP n°6 F-92265, Fontenay-aux-Roses, France,CNRS, Unite de Recherche Associee CEA-CNRS2210, 18 route du panorama, BP n°6 F-92265, Fontenay-aux-Roses, France,CEA, I~2BM, Service Hospitalier Frederic Joliot (SHFJ) 4 place du general Leclerc 91401, Orsay, France,INSERM U1023 Laboratoire d'Imagerie Moleculaire Experimentale 4 place du general Leclerc 91401, Orsay, France,Universite Paris Sud 4 place du general Leclerc 91401, Orsay, France;

    CEA, iBiTecS, Service de Chimie Bioorganique et de Marquage 91191, Gif-sur-Yvette, France;

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