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首页> 外文期刊>Advanced Functional Materials >Release Properties of Pressurized Microgel Templated Capsules
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Release Properties of Pressurized Microgel Templated Capsules

机译：加压微凝胶模板胶囊的释放特性

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摘要

Direction-specific release induced through osmotic pressure inside giant microcapsules is realized and monitored at high and low concentrations of encapsulated polymer. A clear correlation between the release kinetics upon opening the shell and encapsulated polymer concentration is observed. This has been independently confirmed by shell opening via nanoindentation and laser radiation. To quantify these observations, the internal pressure of the capsules is determined by analysis of mechanical tests performed via colloidal probe AFM. As expected, larger amounts of encapsulated material lead to increased internal pressures and enhanced release kinetics. The results show how drug release can be accelerated by encapsulation of osmotic pressure generating species. Such pressurized capsules systems show large ejection velocities and are envisioned as an inexpensive biolistic transfection device for in vitro applications.
机译：通过在高和低浓度的封装聚合物中实现并监控通过巨型微胶囊内部的渗透压诱导的方向特异性释放。观察到打开壳时的释放动力学与包封的聚合物浓度之间存在明显的相关性。这已经通过纳米压痕和激光辐射打开壳而得到独立确认。为了量化这些观察结果，通过对经由胶体探针AFM进行的机械测试的分析来确定胶囊的内部压力。如预期的那样，大量的包封材料导致内部压力增加和释放动力学增强。结果表明如何通过包裹渗透压产生物质来加速药物释放。这样的加压胶囊系统显示出大的喷射速度，并且被设想为用于体外应用的便宜的生物弹射转染装置。

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  • 来源
    《Advanced Functional Materials》 |2011年第8期|p.1411-1418|共8页
  • 作者

    Stephan Schmidt; Paulo A. L Femandes; Bruno C. De Ceest; Mihaela Delcea; Andre G. Skirtach; Helmuth Mohwald; Andreas Fery;

  • 作者单位

    Max Planck Institute of Colloids and Interfaces Interfaces Department Am Muhlenberg 1, 14476 Potsdam, Germany;

    Max Planck Institute of Colloids and Interfaces Interfaces Department Am Muhlenberg 1, 14476 Potsdam, Germany;

    Laboratory of Pharmaceutical Technology Department of Pharmaceutics Ghent University Harelbekestraat 72, 9000 Ghent, Belgium;

    Max Planck Institute of Colloids and Interfaces Interfaces Department Am Muhlenberg 1, 14476 Potsdam, Germany;

    Max Planck Institute of Colloids and Interfaces Interfaces Department Am Muhlenberg 1, 14476 Potsdam, Germany;

    Max Planck Institute of Colloids and Interfaces Interfaces Department Am Muhlenberg 1, 14476 Potsdam, Germany;

    Physikalische Chemie II Universitat Bayreuth Universitatsstrasse 30, D-95447 Bayreuth, Germany;

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