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首页> 外文期刊>Advanced Functional Materials >Vapor-Phase Deposition of Monofunctional Alkoxysilanes for Sub-Nanometer-Level Biointerfacing on Silicon Oxide Surfaces
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Vapor-Phase Deposition of Monofunctional Alkoxysilanes for Sub-Nanometer-Level Biointerfacing on Silicon Oxide Surfaces

机译：单功能烷氧基硅烷的气相沉积用于氧化硅表面上亚纳米级的生物接口

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摘要

Improving the performance and lowering the analyte detection limits of optical and electronic biosensors is essential for advancing wide ranging applications in diagnostics and drug discovery. Most sensing methods require direct linkage of a recognition element and a sensor, which is commonly accomplished through an organic monolayer interface. Alkoxyorganosilanes are typically used to prepare sensor surfaces on dielectric oxides. However, many silanes lead to roughened or thick interfaces that degrade device sensitivity. Here, controlled vapor phase deposition of monoalkoxysilanes is found to lead to monolayers resistant to elevated temperatures and extreme pH conditions. The formation of high density, subnanometer monolayers is demonstrated by ellipsometry, XPS, and AFM. The uniform attachment of these monofunctional silanes to such biosensing platforms as microarrays, field effect devices, and the formation of surface enhanced Raman spectroscopy substrates is demonstrated. The advantages of using this silane deposition protocol for the above technologies are also discussed.
机译：光学和电子生物传感器的性能提高和分析物检测限的降低对于推进诊断和药物发现中的广泛应用至关重要。大多数传感方法需要识别元件和传感器直接链接，这通常是通过有机单层界面实现的。烷氧基有机硅烷通常用于在介电氧化物上制备传感器表面。但是，许多硅烷会导致界面变粗糙或变厚，从而降低器件灵敏度。在此，发现单烷氧基硅烷的受控气相沉积导致单层耐高温和极端pH条件。椭圆偏振法，XPS和AFM证明了高密度亚纳米单层的形成。这些单官能硅烷均匀地附着在生物传感平台上，如微阵列，场效应器件，以及表面增强拉曼光谱衬底的形成。还讨论了将硅烷沉积方案用于上述技术的优势。

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  • 来源
    《Advanced Functional Materials》 |2010年第1期|87-95|共9页
  • 作者

    Brian Dorvel; Bobby Reddy Jr.; Ian Block; Patrick Mathias; Susan E. Clare; Brian Cunningham; Donald E. Bergstrom; Rashid Bashir;

  • 作者单位

    Micro and Nanotechnology Laboratory 208 North Wright Street Urbana, Illinois 61801 (USA) Department of Biophysics and Computational Biology University of Illinois Urbana-Champaign Urbana, IL 61801 (USA);

    rnMicro and Nanotechnology Laboratory 208 North Wright Street Urbana, Illinois 61801 (USA) Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign Urbana, IL 61801 (USA);

    rnMicro and Nanotechnology Laboratory 208 North Wright Street Urbana, Illinois 61801 (USA) Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign Urbana, IL 61801 (USA);

    rnMicro and Nanotechnology Laboratory 208 North Wright Street Urbana, Illinois 61801 (USA) Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign Urbana, IL 61801 (USA);

    rnIndiana University School of Medicine Indianapolis, IN 46202 (USA);

    Micro and Nanotechnology Laboratory 208 North Wright Street Urbana, Illinois 61801 (USA) Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign Urbana, IL 61801 (USA) Department of Bioengineering University of Illinois at Urbana-Champaign Urbana, IL 61801 (USA);

    rnDepartment of Medicinal Chemistry and Molecular Pharmacology Birck Nanotechnology Center Purdue University West Lafayette, IN 47097 (USA);

    rnMicro and Nanotechnology Laboratory 208 North Wright Street Urbana, Illinois 61801 (USA) Department of Electrical and Computer Engineering University of Illinois Urbana-Champaign Urbana, IL 61801 (USA) Department of Bioengineering University of Illinois at Urbana-Champaign Urbana, IL 61801 (USA);

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