Nanoshells with Targeted Simultaneous Enhancement of Magnetic and Optical Imaging and Photothermal Therapeutic Response

Rizia Bardhan; Wenxue Chen; Carlos Perez-Torres; Marc Bartels; Ryan M. Huschka; Liang L. Zhao; Emilia Morosan; Robia G. Pautler; Amit Joshi; Naomi J. Halas

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Nanoshells with Targeted Simultaneous Enhancement of Magnetic and Optical Imaging and Photothermal Therapeutic Response

机译：有目标的同时增强磁和光成像和光热治疗反应的纳米壳。

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Integrating multiple functionalities into individual nanoscale complexes is of tremendous importance in biomedicine, expanding the capabilities of nanoscale structures to perform multiple parallel tasks. Here, the ability to enhance two different imaging technologies simultaneously-fluorescence optical imaging and magnetic resonance imaging-with antibody targeting and photothermal therapeutic actuation is combined all within the same nanoshell-based complex. The nanocomplexes are constructed by coating a gold nanoshell with a silica epilayer doped with Fe_3O_4 and the fluorophore ICG, which results in a high T_2 relaxivity (390 mM~(-1) s~(-1)) and 45× fluorescence enhancement of ICG. Bioconjugate nanocomplexes target HER2+ cells and induce photothermal cell death upon near-IR illumination.

机译：在生物医学中，将多种功能整合到单个纳米级复合物中非常重要，这可以扩展纳米级结构执行多种并行任务的能力。在这里，同时增强两种不同成像技术的能力-荧光光学成像和磁共振成像-抗体靶向和光热治疗启动，都结合在同一基于纳米壳的复合物中。通过用掺杂有Fe_3O_4和荧光团ICG的二氧化硅外延层涂覆金纳米壳来构建纳米复合物，这导致高T_2弛豫度（390 mM〜（-1）s〜（-1））和ICG的45倍荧光增强。生物共轭纳米复合物靶向HER2 +细胞，并在近红外照明下诱导光热细胞死亡。

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《Advanced Functional Materials》 |2009年第24期|3901-3909|共9页
作者
Rizia Bardhan; Wenxue Chen; Carlos Perez-Torres; Marc Bartels; Ryan M. Huschka; Liang L. Zhao; Emilia Morosan; Robia G. Pautler; Amit Joshi; Naomi J. Halas;
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Department of Chemistry Rice University, Houston, TX 77005 (USA);

Department of Radiology Baylor College of Medicine Houston, TX 77005 (USA);

Department of Molecular Physiology and Biophysics Baylor College of Medicine Houston, TX 77005 (USA);

Department of Radiology Baylor College of Medicine Houston, TX 77005 (USA);

Department of Chemistry Rice University, Houston, TX 77005 (USA);

Department of Physics and Astronomy Rice University Houston, TX 77005 (USA);

Department of Physics and Astronomy Rice University Houston, TX 77005 (USA);

Department of Molecular Physiology and Biophysics Baylor College of Medicine Houston, TX 77005 (USA);

Department of Radiology Baylor College of Medicine Houston, TX 77005 (USA);

Department of Chemistry Rice University, Houston, TX 77005 (USA) Departments of Electrical and Computer Engineering and Bioengineering Rice University, Houston, TX 77005 (USA);

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1. Simultaneous Enhancement of Intracellular Optical Imaging and Photothermal Therapeutic Response by Octaarginine-Modified Fluorescent Dye Doped Pd@Ag@SiO2(RITC) Multifunctional Nanoparticles [J] . Shi Saige, Zhu Xianglong, Huang Yizhuan, Journal of nanoscience and nanotechnology . 2015,第2期

机译：八精氨酸修饰的荧光染料掺杂Pd @ Ag @ SiO2（RITC）多功能纳米粒子同时增强细胞内光学成像和光热治疗反应。
2. Au nanoshell-coated superparamagnetic Fe3O4-silica composite nanoparticles with surface-modification of an activatable cell-penetrating peptide for tumor-targeted multimode bioimaging and photothermal therapy [J] . Jiang Yunfang, Zhang Qianyu, Liu Xinghua, RSC Advances . 2016,第88期

机译：Au纳米孔涂覆的超顺磁Fe3O4-二氧化硅复合纳米颗粒，具有用于肿瘤靶向多模生物成像和光热疗的可活化细胞渗透肽的表面改性
3. Encapsulated Fe_3O_4/Ag Complexed Cores in Hollow Gold Nanoshells for Enhanced Theranostic Magnetic Resonance Imaging and Photothermal Therapy [J] . Adam Y. Lin, Joseph K. Young, Ariel V. Nixon, Small . 2014,第16期

机译：空心金纳米壳中包裹的Fe_3O_4 / Ag复合核，用于增强的治疗声波磁共振成像和光热疗法
4. Targeted photothermal tumor therapy using metal nanoshells [C] . Hirsch, L.R., Stafford, . 2002

机译：使用金属纳米壳的靶向光热肿瘤疗法
5. Simultaneous integrated functional magnetic resonance imaging and optical tomography in the near infrared spectrum (SINFONIS) for studying hemodynamic and neuronal responses in the human brain. [D] . Zhang, Xiaofeng. 2005

机译：同时集成近红外光谱的功能磁共振成像和光学层析成像（SINFONIS），用于研究人脑中的血液动力学和神经元反应。
6. Acute cellular and vascular responses to photodynamic therapy using EGFR-targeted nanobody-photosensitizer conjugates studied with intravital optical imaging and magnetic resonance imaging [O] . Henriette S. de Bruijn, Vida Mashayekhi, Tom J.L. Schreurs, 2020

机译：使用活体光学成像和磁共振成像研究EGFR靶向纳米抗体-光敏剂偶联物对光动力疗法的急性细胞和血管反应
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机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。

Nanoshells with Targeted Simultaneous Enhancement of Magnetic and Optical Imaging and Photothermal Therapeutic Response

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