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Designer Biomaterials for Nanomedicine

机译：纳米医学的设计师生物材料

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摘要

Nanotechnology has had tremendous impact on medical science and has resulted in phenomenal progress in the field of drug delivery and diagnostics. A wide spectrum of novel nanomaterials including polymeric particles, liposomes, quantum dots, and iron oxide particles have been developed for applications in therapeutic delivery and diagnostics. This has resulted in control over the rate and period of delivery and targeting of drugs to specific organs in the human body. This feature article focuses on the delivery of drugs using polymeric particles. The size, choice of polymer, surface chemistry, shape, and mechanical properties of the particles are parameters that critically affect particle function. Numerous biomaterials and fabrication techniques have been developed in the last decade that focus on novel design parameters, such as shape and mechanical properties and the interplay of these parameters with the size and surface chemistry of particles. Recent advances with particular focus on the importance of particle shape are highlighted, and the challenges that are yet to be fulfilled are underscored.
机译：纳米技术对医学产生了巨大影响，并在药物输送和诊断领域取得了惊人的进步。已经开发出包括聚合物颗粒，脂质体，量子点和氧化铁颗粒在内的各种新型纳米材料，用于治疗性递送和诊断。这导致了对药物输送到人体特定器官的速率和周期以及靶向药物的控制。这篇专题文章重点介绍使用聚合物颗粒的药物递送。颗粒的大小，聚合物的选择，表面化学性质，形状和机械性能是严重影响颗粒功能的参数。在过去的十年中，已经开发了许多生物材料和制造技术，这些技术专注于新颖的设计参数，例如形状和机械性能以及这些参数与颗粒的尺寸和表面化学的相互作用。着重指出了最近的进展，特别是关注颗粒形状的重要性，并强调了尚未解决的挑战。

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  • 来源
    《Advanced Functional Materials》 |2009年第24期|3843-3854|共12页
  • 作者

    Nishit Doshi; Samir Mitragotri;

  • 作者单位

    Department of Chemical Engineering University of California Santa Barbara, CA 93 106 (USA);

    Department of Chemical Engineering University of California Santa Barbara, CA 93106 (USA);

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