Dextran Microgels for Time-Controlled Delivery of siRNA

Koen Raemdonck; Tinneke G. Van Thienen; Roosmarijn E. Vandenbroucke; Niek N. Sanders; Joseph Demeester; Stefaan C. De Smedt

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Dextran Microgels for Time-Controlled Delivery of siRNA

机译：用于时间控制的siRNA的Dextran微凝胶

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To apply siRNA as a therapeutic agent, appropriate attention should be paid to the optimization of the siRNA gene silencing effect, both in terms of magnitude and duration. Intracellular time-controlled siRNA delivery could aid in tailoring the kinetics o

机译：要将siRNA用作治疗剂，就大小和持续时间而言，应适当注意siRNA基因沉默效果的优化。细胞内时间控制的siRNA传递可能有助于调整动力学

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《Advanced Functional Materials》 |2008年第7期|p.993-1001|共9页
作者
Koen Raemdonck; Tinneke G. Van Thienen; Roosmarijn E. Vandenbroucke; Niek N. Sanders; Joseph Demeester; Stefaan C. De Smedt;
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作者单位

Laboratory of General Biochemistry and Physical Pharmacy, Department of Pharmaceutics Faculty of Pharmaceutical Sciences, Ghent University Harelbekestraat 72, 9000 Ghent (Belgium);

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正文语种 eng
中图分类无线电电子学、电信技术;
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1. Conjugation Chemistry through Acetals toward a Dextran-Based Delivery System for Controlled Release of siRNA [J] . Lina Cui, Jessica L. Cohen, Crystal K. Chu, Journal of the American Chemical Society . 2012,第38期

机译：通过缩醛进行共轭化学合成，以基于葡聚糖的传递系统控制siRNA的释放
2. Poly-L-arginine and Dextran Sulfate-Based Nanocomplex for Epidermal Growth Factor Receptor (EGFR) siRNA Delivery: Its Application for Head and Neck Cancer Treatment [J] . Hyun-Jong Cho, Saeho Chong, Suk-Jae Chung, Pharmaceutical Research . 2012,第4期

机译：基于聚L-精氨酸和硫酸葡聚糖的纳米复合物用于表皮生长因子受体（EGFR）siRNA的递送：在头颈癌治疗中的应用
3. Poly-L-arginine and dextran sulfate-based nanocomplex for epidermal growth factor receptor (EGFR) siRNA delivery: its application for head and neck cancer treatment. [J] . Hyun-Jong Cho, Saeho Chong, Suk-Jae Chung, Pharmaceutical research . 2012,第4期

机译：基于聚L-精氨酸和硫酸葡聚糖的纳米复合物，用于表皮生长因子受体（EGFR）siRNA的递送：其在头颈癌治疗中的应用。
4. Thermoresponsive and Biodegradable Dextran Based Microgels: Synthesis and Structural Investigation [C] . Shivkumar V. Ghugare, Ester Chiessi, Victoria Garcia Sakai Polymer Networks Group Meeting . 2013

机译：热响应性和可生物降解的葡聚糖微凝块：合成与结构调查
5. Investigation of a time-controlled release drug delivery system: Particulate-filled polymer effect on drug release. [D] . Reo, Joseph P. 1998

机译：时间控制释放药物输送系统的研究：颗粒填充的聚合物对药物释放的影响。
6. PD-L1 siRNA Theranostics With a Dextran Nanoparticle Highlights the Importance of Nanoparticle Delivery for Effective Tumor PD-L1 Downregulation [O] . Jesus Pacheco-Torres, Marie-France Penet, Balaji Krishnamachary, 2020

机译：具有葡聚糖纳米粒子的PD-L1 siRNA Theranostics突出了纳米颗粒递送在有效肿瘤PD-L1下调的重要性
7. PEGylation of biodegradable dextran nanogels for siRNA delivery [O] . Naeye Broes, Raemdonck Koen, Remaut Katrien, 2010

机译：可生物降解的葡聚糖纳米凝胶的pEG化用于siRNa递送
8. Research Area 14.3 Microbiology and Biodegradation: Development of RNA-based Vectors for in vivo Delivery of siRNAs. [R] . TenOever, B. 2014

机译：研究领域14.3微生物学和生物降解：用于体内递送siRNa的基于RNa的载体的开发。

Dextran Microgels for Time-Controlled Delivery of siRNA

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