Intracellular Dynamic Assembly of Deep-Red Emitting Supramolecular Nanostructures Based on the Pt...Pt Metallophilic Interaction

Zhou Xue-Quan; Mytiliniou Maria; Hilgendorf Jonathan; Zeng Ye; Papadopoulou Panagiota; Shao Yang; Dominguez Maximilian Paradiz; Zhang Liyan; Hesselberth Marcel B. S.; Bos Erik; Siegler Maxime A.; Buda Francesco; Brouwer Albert M.; Kros Alexander; Koning Roman I; Heinrich Doris; Bonnet Sylvestre

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Intracellular Dynamic Assembly of Deep-Red Emitting Supramolecular Nanostructures Based on the Pt...Pt Metallophilic Interaction

机译：基于Pt ... Pt金属相互作用的深红色发射超分子纳米结构的细胞内动态组装

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Many drug delivery systems end up in the lysosome because they are built from covalent or kinetically inert supramolecular bonds. To reach other organelles, nanoparticles hence need to either be made from a kinetically labile interaction that allows re-assembly of the nanoparticles inside the cell following endocytic uptake, or, be taken up by a mechanism that short-circuits the classical endocytosis pathway. In this work, the intracellular fate of nanorods that self-assemble via the Pt horizontal ellipsis Pt interaction of cyclometalated platinum(II) compounds, is studied. These deep-red emissive nanostructures (638 nm excitation, approximate to 700 nm emission) are stabilized by proteins in cell medium. Once in contact with cancer cells, they cross the cell membrane via dynamin- and clathrin-dependent endocytosis. However, time-dependent confocal colocalization and cellular electron microscopy demonstrate that they directly move to mitochondria without passing by the lysosomes. Altogether, this study suggests that Pt horizontal ellipsis Pt interaction is strong enough to generate emissive, aggregated nanoparticles inside cells, but labile enough to allow these nanostructures to reach the mitochondria without being trapped in the lysosomes. These findings open new venues to the development of bioimaging nanoplatforms based on the Pt horizontal ellipsis Pt interaction.

机译：许多药物递送系统最终在溶酶体中，因为它们是由共价或动态惰性的超分子键构成的。为了到达其他细胞器，因此需要由动力学相互作用进行纳米颗粒，其允许在细胞内重新组装细胞内的纳米粒子后，或者通过短路古代内吞炎途径短路的机制来吸收。在这项工作中，研究了通过Pt水平椭圆形Pt相互作用的纳米棒的细胞内命运进行了研究，该纳米散液通过环状铂（II）化合物的Pt水平椭圆形Pt相互作用。这些深红发射纳米结构（638nm激发，近似为700nm发射）通过细胞培养基中的蛋白质稳定。一旦与癌细胞接触，它们通过动力学和克拉螯肽依赖性内吞作用通过细胞膜。然而，时间依赖的共聚焦分层化和蜂窝电子显微镜证明它们直接移动到线粒体而不通过溶酶体。完全，该研究表明，PT水平椭圆形Pt相互作用足以产生发光，聚集的纳米颗粒，但足以允许这些纳米结构到达线粒体而不被捕获在溶酶体中。这些发现基于PT水平椭圆形PT相互作用开辟了新的场所到开发生物瘤纳米载物。

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来源
《Advanced Materials》 |2021年第37期|2008613.1-2008613.13|共13页
作者
Zhou Xue-Quan; Mytiliniou Maria; Hilgendorf Jonathan; Zeng Ye; Papadopoulou Panagiota; Shao Yang; Dominguez Maximilian Paradiz; Zhang Liyan; Hesselberth Marcel B. S.; Bos Erik; Siegler Maxime A.; Buda Francesco; Brouwer Albert M.; Kros Alexander; Koning Roman I; Heinrich Doris; Bonnet Sylvestre;
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作者单位

Leiden Univ Leiden Inst Chem Einsteinweg 55 NL-2333 CC Leiden Netherlands;

Leiden Univ Huygens Kamerlingh Onnes Lab Leiden Inst Phys NL-2300 RA Leiden Netherlands;

Leiden Univ Leiden Inst Chem Einsteinweg 55 NL-2333 CC Leiden Netherlands;

Leiden Univ Leiden Inst Chem Einsteinweg 55 NL-2333 CC Leiden Netherlands;

Leiden Univ Leiden Inst Chem Einsteinweg 55 NL-2333 CC Leiden Netherlands;

Leiden Univ Leiden Inst Chem Einsteinweg 55 NL-2333 CC Leiden Netherlands;

Univ Amsterdam Vant Hoff Inst Mol Sci HIMS Mol Photon Grp Sci Pk 904 NL-1098 XH Amsterdam Netherlands;

Leiden Univ Leiden Inst Chem Einsteinweg 55 NL-2333 CC Leiden Netherlands;

Leiden Univ Huygens Kamerlingh Onnes Lab Leiden Inst Phys NL-2300 RA Leiden Netherlands;

Leiden Univ Med Ctr Dept Cell & Chem Biol Einthovenweg 20 NL-2333 ZC Leiden Netherlands;

Johns Hopkins Univ Dept Chem Baltimore MD 21218 USA;

Leiden Univ Leiden Inst Chem Einsteinweg 55 NL-2333 CC Leiden Netherlands;

Univ Amsterdam Vant Hoff Inst Mol Sci HIMS Mol Photon Grp Sci Pk 904 NL-1098 XH Amsterdam Netherlands|Adv Res Ctr Nanolithog Mat Dept Sci Pk 106 NL-1098 XG Amsterdam Netherlands;

Leiden Univ Leiden Inst Chem Einsteinweg 55 NL-2333 CC Leiden Netherlands;

Leiden Univ Med Ctr Dept Cell & Chem Biol Einthovenweg 20 NL-2333 ZC Leiden Netherlands;

Leiden Univ Huygens Kamerlingh Onnes Lab Leiden Inst Phys NL-2300 RA Leiden Netherlands|Inst Bioproc & Analyt Measurement Tech D-37308 Heilbad Heiligenstadt Germany|Ilmenau Univ Technol Fac Math & Nat Sci D-98693 Ilmenau Germany|Fraunhofer Inst Silicate Res ISC Frauenhofer Attract 3DNanoCell D-97082 Wurzburg Germany;

Leiden Univ Leiden Inst Chem Einsteinweg 55 NL-2333 CC Leiden Netherlands;

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正文语种 eng
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关键词
cyclometalation; electronic microscopy (EM); live cell imaging; nanoparticle; Pt horizontal ellipsis Pt metallophilic interaction; self-assembly;

机译：环芯;电子显微镜（EM）;活细胞成像;纳米粒子;Pt水平椭圆磷脂酰胺相互作用;自组装;

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1. Platinum(II)-Based Supramolecular Scaffold-Templated Side-by-Side Assembly of Gold Nanorods through Pt...Pt and pi-pi Interactions [J] . Wong Yip-Sang, Leung Frankie Chi-Ming, Ng Maggie, Angewandte Chemie . 2018,第48期

机译：通过pt ... pt和pi-pi相互作用基于铂（ii）基于铂金支架模板的金纳米棒的旁边组装
2. Selenadiazolopyridine: A Synthon for Supramolecular Assembly and Complexes with Metallophilic Interactions [J] . Goutam Mukherjee, † Puspendra Singh, † Chandrasekhar Ganguri, Inorganic Chemistry . 2012,第15期

机译：Selenadiazolopyridine：超分子组装和嗜金属相互作用的复合体。
3. Aurophilicity versus mercurophilicity: Impact of d ~(10)-d~(10) metallophilic interactions on the structure of metal-rich supramolecular assemblies [J] . Vreshch V., Shen W., Nohra B., Chemistry: A European journal . 2012,第2期

机译：嗜酸性与嗜酸性：d〜（10）-d〜（10）嗜金属相互作用对富金属超分子组装体结构的影响
4. Long-Living Emitting Electrochemical Cells Based on Supramolecular π-π Interactions [C] . Ruben D. Costa, Henk J. Bolink, Enrique Orti, MRS Meeting . 2010

机译：基于超分子π-π相互作用的长寿命发射电化学电池
5. Multivalent interactions based on supramolecular self-assembly and peptide-labeled quantum dots for imaging GPCRs. [D] . Zhou, Min. 2006

机译：基于超分子自组装和肽标记的量子点的多价相互作用，用于GPCR成像。
6. Supramolecular assembly of a phosphole-based moiety into nanostructures dictated by alkynylplatinum(ii) terpyridine complexes through non-covalent Pt···Pt and π–π stacking interactions: synthesis characterization photophysics and self-assembly behaviors [O] . Sammual Yu-Lut Leung, Sloane Evariste, Christophe Lescop, 2017

机译：通过非共价Pt···Pt和π–π堆积相互作用将基于磷脂的部分超分子组装为炔基铂（ii）吡啶吡啶配合物所决定的纳米结构：合成表征光物理和自组装行为
7. Supramolecular assembly of a phosphole-based moiety into nanostructures dictated by alkynylplatinum( ii ) terpyridine complexes through non-covalent Pt⋯Pt and π–π stacking interactions: synthesis, characterization, photophysics and self-assembly behaviors [O] . Leung, Sammual Yu-Lut, Evariste, Sloane, Lescop, Christophe, 2017

机译：通过非共价Pt⋯Pt和π–π堆积相互作用将基于磷的部分超分子组装成由炔基铂（ii）联吡啶配合物决定的纳米结构：合成，表征，光物理和自组装行为
8. Inducing the Formation of Functional Macroscopic Assemblies Through Programmed Orthogonal Supramolecular Interactions [R] . Braunschweig, AB 2014

机译：通过程序正交超分子相互作用诱导功能性宏观组装的形成

Intracellular Dynamic Assembly of Deep-Red Emitting Supramolecular Nanostructures Based on the Pt...Pt Metallophilic Interaction

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