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首页> 外文期刊>AIDS Research and Human Retroviruses >Viral and Host Correlates of Serum Resistin in Simian AIDS
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Viral and Host Correlates of Serum Resistin in Simian AIDS

机译：猿猴艾滋病患者血清抵抗素的病毒和宿主相关性

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Resistin is an adipocytokine with a proposed dual role in metabolism and inflammation. In light of the ability to promote inflammatory responses, adipocytokines may prove key factors in modulating the host response to HIV. This study utilizes the simian immunodeficiency virus (SIV) model of HIV/AIDS to investigate changes in serum resistin levels following dietary intervention and SIV infection and determine associations with measures of body composition and disease severity. Resistin levels, body composition (n = 34), and insulin resistance (n = 16) were determined in healthy rhesus macaques. A subset of animals (n = 8) was placed on an atherogenic diet (AD) and subsequently inoculated with SIVmac239. Longitudinal measures of serum resistin, cytokines, viral load, lymphocyte subsets, and body composition were obtained. In healthy macaques consuming a standard diet, resistin levels correlated positively with total fat mass (r = 0.49; p < 0.01) and tissue fat percent (r = 0.53; p < 0.01) but failed to associate with measures of insulin resistance. In contrast, a negative correlation was noted between these measures of adiposity and resistin following SIV inoculation (r = −0.27; p < 0.05 and r = −0.24; p < 0.05, respectively). Viral load correlated positively with serum resistin (r = 0.32; p < 0.01). Serum levels of MCP-1 and sTNF RII demonstrated no correlation with resistin in normal animals on a standard diet, while a significant positive correlation was observed following SIV infection (r = 0.52; p < 0.0001 and r = 0.59; p < 0.0001, respectively). Findings indicate a fundamental difference in the relationship between resistin and body composition following SIV infection and suggest that elevations in resistin parallel measures of disease severity including loss of body fat and viral replication.
机译：抵抗素是一种脂肪细胞因子，在代谢和炎症中具有双重作用。考虑到促进炎症反应的能力，脂肪细胞因子可能是调节宿主对HIV反应的关键因素。这项研究利用HIV / AIDS的猿猴免疫缺陷病毒（SIV）模型调查饮食干预和SIV感染后血清抵抗素水平的变化，并确定与身体成分和疾病严重程度的相关性。在健康的恒河猴中确定了抵抗素水平，身体成分（n = 34）和胰岛素抵抗（n = 16）。将一部分动物（n = 8）置于致动脉粥样化的饮食（AD）上，随后接种SIVmac239。纵向测量血清抵抗素，细胞因子，病毒载量，淋巴细胞亚群和身体组成。在食用标准饮食的健康猕猴中，抵抗素水平与总脂肪量（r = 0.49； p <0.01）和组织脂肪百分比（r = 0.53； p <0.01）呈正相关，但与胰岛素抵抗的测量值没有关联。相反，在SIV接种后，这些肥胖与抵抗素的测量值之间存在负相关（分别为r = -0.27； p <0.05和r = -0.24； p <0.05）。病毒载量与血清抵抗素呈正相关（r = 0.32； p <0.01）。正常饮食中正常动物的血清MCP-1和sTNF RII水平与抵抗素无相关性，而SIV感染后观察到显着正相关性（r = 0.52; p <0.0001和r = 0.59; p <0.0001 ）。研究结果表明，SIV感染后抵抗素和身体成分之间关系的根本差异，并表明抵抗素的升高与疾病严重程度（包括体内脂肪的损失和病毒复制）的并行测量有关。

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