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Screening Neuropharmacological Activities of Kaempferia parviflora (Krachai Dam) in Healthy Adult Male Rats

机译:健康成年雄性大鼠Kaempferia parviflora(Krachai Dam)神经药理活性的筛选

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Problem statement: Although the global prevalence ot psychological disorders is increasing continually, the efficacies of therapeutic strategies are still very limited. Oxidative stress has been implicated in the pathogenesis of psychiatric disorders and substance possessing antioxidant activity can alleviate the mentioned conditions. Therefore, we hypothesized that Kaempferia parviflora, a medicinal plant claimed for nerve tonic, also possessed the neuropharmacological activities which provide the advantage for psychiatric disorders. Approach: Adult male Wistar rats, weighing 180-220 grams, were orally given the ethanolic extract of K. parviflora at doses of 150, 200 and 250 mg kg"1 BW once daily for 2 weeks. Then, they were determined the neuropharmacological activities including anxiolytic, anti-depression like behavior and cognitive enhancement after single dose, 1 and 2 weeks of treatment. Results: K. parviflora possessed anti-depression like behavior and cognitive enhancement at all treatment duration. Unfortunately, this substance failed to show anxiolytic like activity. Conclusion: Our results suggested that K. parviflora might be used as a novel therapeutic strategy for psychiatric disorder and cognitive enhancement. However, further investigations about precise underlying mechanism are still required.
机译:问题陈述:尽管全球心理疾病的患病率持续增加,但是治疗策略的效果仍然非常有限。氧化应激与精神疾病的发病机理有关,具有抗氧化活性的物质可以缓解上述疾病。因此,我们假设Kaempferia parviflora,一种声称具有神经滋补作用的药用植物,还具有神经药理活性,为精神疾病提供了优势。方法:雄性成年雄性Wistar大鼠,体重180-220克,每天口服150、200和250 mg kg“ 1 BW的剂量的小花K.的乙醇提取物,持续2周,然后测定其神经药理活性。结果显示:小花K. parviflora在所有治疗期间均具有抗抑郁样的行为和认知功能增强,但这种物质未能表现出类似抗焦虑的行为。结论:我们的研究结果提示小花K. parviflora可能被用作治疗精神疾病和认知增强的新方法,但仍需要进一步研究确切的潜在机制。

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