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首页> 外文期刊>American journal of applied sciences >Screening Neuropharmacological Activities of Kaempferia parviflora (Krachai Dam) in Healthy Adult Male Rats | Science Publications
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Screening Neuropharmacological Activities of Kaempferia parviflora (Krachai Dam) in Healthy Adult Male Rats | Science Publications

机译：健康成年雄性大鼠Kaempferia parviflora（Krachai Dam）神经药理活性的筛选科学出版物

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> Problem statement: Although the global prevalence of psychological disorders is increasing continually, the efficacies of therapeutic strategies are still very limited. Oxidative stress has been implicated in the pathogenesis of psychiatric disorders and substance possessing antioxidant activity can alleviate the mentioned conditions. Therefore, we hypothesized that Kaempferia parviflora, a medicinal plant claimed for nerve tonic, also possessed the neuropharmacological activities which provide the advantage for psychiatric disorders. Approach: Adult male Wistar rats, weighing 180-220 grams, were orally given the ethanolic extract of K. parviflora at doses of 150, 200 and 250 mg kg-1 BW once daily for 2 weeks. Then, they were determined the neuropharmacological activities including anxiolytic, anti-depression like behavior and cognitive enhancement after single dose, 1 and 2 weeks of treatment. Results: K. parviflora possessed anti-depression like behavior and cognitive enhancement at all treatment duration. Unfortunately, this substance failed to show anxiolytic like activity. Conclusion: Our results suggested that K. parviflora might be used as a novel therapeutic strategy for psychiatric disorder and cognitive enhancement. However, further investigations about precise underlying mechanism are still required.
机译： > 问题陈述：尽管全球心理疾病的患病率持续增长，但治疗策略的效果仍然非常有限。氧化应激与精神疾病的发病机理有关，具有抗氧化活性的物质可以缓解上述疾病。因此，我们推测，声称有神经滋补作用的药用植物 Kaempferia parviflora 也具有神经药理活性，为精神疾病提供了优势。 方法：体重为180-220克的成年雄性Wistar大鼠经口给予 K乙醇提取物。每日一次，剂量分别为150、200和250 mg kg -1 BW的小花蜜，持续2周。然后，确定他们在单剂，治疗1和2周后的神经药理活性，包括抗焦虑药，抗抑郁样行为和认知增强。 结果： K。在所有治疗期间，parviflora 均具有抗抑郁样的行为和认知功能。不幸的是，该物质未能显示出抗焦虑活性。 结论：我们的结果表明 K。 parviflora 可能被用作治疗精神疾病和增强认知能力的新型治疗策略。但是，仍然需要进一步研究精确的潜在机制。

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