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首页> 外文期刊>American Journal of Neuroradiology >Cerebral Hemodynamics in Asymptomatic Patients with Internal Carotid Artery Occlusion: A Dynamic Susceptibility Contrast MR and Transcranial Doppler Study
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Cerebral Hemodynamics in Asymptomatic Patients with Internal Carotid Artery Occlusion: A Dynamic Susceptibility Contrast MR and Transcranial Doppler Study

机译:无症状颈内动脉闭塞患者的脑血流动力学:动态敏感性对比MR和经颅多普勒研究

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摘要

BACKGROUND AND PURPOSE: Perfusion imaging with dynamic susceptibility contrast MR imaging (DSC-MRI) has been used to evaluate hemodynamic status in patients with symptomatic occlusive cerebrovascular disease. The aim of the present study was to determine the hemodynamic changes occurring in asymptomatic patients with unilateral internal carotid artery (ICA) occlusion by use of DSC-MRI with transcranial Doppler (TCD) measurement of the breath-holding index (BHI). METHODS: Nine patients with asymptomatic unilateral ICA occlusion underwent DSC-MRI and TCD examination. One patient was excluded from final analysis because of severe movement artifacts. On a separate workstation, regional cerebral blood volume (rCBV), regional cerebral blood flow (rCBF), and regional mean time to peak (rMTT) were calculated on the basis of signal decay rate during the passage of gadolinium bolus through the sampled volume in the territory of the middle cerebral artery. TCD-BHI was calculated in all patients. Six healthy subjects underwent the same MR protocol as the patients. RESULTS: Compared with control subjects, patients with unilateral ICA occlusions had hemodynamic changes in the ipsilateral hemisphere: rCBF was significantly lower than in controls (P < .01), and r MTT was significantly increased in both white (WM) and gray matter (GM) in the affected side (WM: P < .01; GM: P < .05). No statistically significant difference in rCBV was found in the group of patients (occluded versus contralateral, P < .1) or between the patient and control groups (occluded side versus controls, P < .1). The correlation of rCBV and BHI showed a strong relation of the two variables, showing a decrease of the latter when the former increased. CONCLUSION: DSC-MRI is a valuable tool for measuring hemodynamic changes in the presence of carotid disease with hemodynamic impairment. In our opinion, hemodynamic changes and efficiency of collateral pathways can be evaluated in occlusive carotid disease by using paired measurement of BHI and DSC-MRI. In the patient group, MR-determined rCBV and TCD-determined BHI showed a significant inverse correlation, suggesting similar significance of the two indices.
机译:背景与目的:动态MR灌注成像(DSC-MRI)已被用于评估有症状性闭塞性脑血管疾病的血流动力学状态。 >疾病。本研究的目的是通过DSC-MRI和经颅来确定无症状单侧颈内动脉(ICA)闭塞的无症状患者的血流动力学变化。 多普勒(TCD)测量屏气指数(BHI)。 方法:9例无症状单侧ICA闭塞的患者接受了DSC-MRI和TCD检查。一名患者因严重的运动伪影而被排除在最终分析之外 。在 的单独工作站上,区域脑血流量(rCBV), 区域脑血流量(rCBF)和区域平均时间 达到峰值(rMTT )的计算是基于of药丸通过大脑中部动脉区域的采样体积中的信号衰减 速率。计算所有患者的TCD-BHI 。 6名健康受试者接受了与患者相同的MR方案。 结果:与对照组相比,单侧 ICA闭塞的患者的血流动力学改变。同侧半球: rCBF显着低于对照组(P <.01), ,r MTT在白人(WM)和 患侧的灰质(GM)(WM:P <.01; GM:P <.05)。在患者组(闭塞与对侧, P <.1)或患者与对照组(闭塞 < / sup>侧与控件之间,P <.1)。 rCBV和 BHI的相关性表明这两个变量之间具有很强的相关性,当前者增加时,后者的 减少。 结论:DSC -MRI是在有血流动力学 损害的颈动脉疾病存在时测量血流动力学 变化的有价值的工具。我们认为,可以通过BHI和DSC-MRI的配对测量来评估闭塞性颈动脉疾病的血流动力学变化和侧支通路的效率 。在 患者组中,由MR确定的rCBV和由TCD确定的BHI显示 显着的负相关,表明两个指数的显着性 。 sup>

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  • 来源
    《American Journal of Neuroradiology》 |2001年第6期|1062-1067|共6页
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    From the Istituto Neurotraumatologico Italiano (A.A.), Grottaferrata, Rome, the Department of Radiology (R.F., A.B., S.M., G.S.), University of Rome Tor Vergata, the Department of Neurology (M.S., F.V., C.C.), University of Rome Tor Vergata, and the Foundation S. Lucia (G.H., C.C.), Rome, Italy.;

    From the Istituto Neurotraumatologico Italiano (A.A.), Grottaferrata, Rome, the Department of Radiology (R.F., A.B., S.M., G.S.), University of Rome Tor Vergata, the Department of Neurology (M.S., F.V., C.C.), University of Rome Tor Vergata, and the Foundation S. Lucia (G.H., C.C.), Rome, Italy.;

    From the Istituto Neurotraumatologico Italiano (A.A.), Grottaferrata, Rome, the Department of Radiology (R.F., A.B., S.M., G.S.), University of Rome Tor Vergata, the Department of Neurology (M.S., F.V., C.C.), University of Rome Tor Vergata, and the Foundation S. Lucia (G.H., C.C.), Rome, Italy.;

    From the Istituto Neurotraumatologico Italiano (A.A.), Grottaferrata, Rome, the Department of Radiology (R.F., A.B., S.M., G.S.), University of Rome Tor Vergata, the Department of Neurology (M.S., F.V., C.C.), University of Rome Tor Vergata, and the Foundation S. Lucia (G.H., C.C.), Rome, Italy.;

    From the Istituto Neurotraumatologico Italiano (A.A.), Grottaferrata, Rome, the Department of Radiology (R.F., A.B., S.M., G.S.), University of Rome Tor Vergata, the Department of Neurology (M.S., F.V., C.C.), University of Rome Tor Vergata, and the Foundation S. Lucia (G.H., C.C.), Rome, Italy.;

    From the Istituto Neurotraumatologico Italiano (A.A.), Grottaferrata, Rome, the Department of Radiology (R.F., A.B., S.M., G.S.), University of Rome Tor Vergata, the Department of Neurology (M.S., F.V., C.C.), University of Rome Tor Vergata, and the Foundation S. Lucia (G.H., C.C.), Rome, Italy.;

    From the Istituto Neurotraumatologico Italiano (A.A.), Grottaferrata, Rome, the Department of Radiology (R.F., A.B., S.M., G.S.), University of Rome Tor Vergata, the Department of Neurology (M.S., F.V., C.C.), University of Rome Tor Vergata, and the Foundation S. Lucia (G.H., C.C.), Rome, Italy.;

    From the Istituto Neurotraumatologico Italiano (A.A.), Grottaferrata, Rome, the Department of Radiology (R.F., A.B., S.M., G.S.), University of Rome Tor Vergata, the Department of Neurology (M.S., F.V., C.C.), University of Rome Tor Vergata, and the Foundation S. Lucia (G.H., C.C.), Rome, Italy.;

    From the Istituto Neurotraumatologico Italiano (A.A.), Grottaferrata, Rome, the Department of Radiology (R.F., A.B., S.M., G.S.), University of Rome Tor Vergata, the Department of Neurology (M.S., F.V., C.C.), University of Rome Tor Vergata, and the Foundation S. Lucia (G.H., C.C.), Rome, Italy.;

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