Spirometric Correlates of Improvement in Exercise Performance after Anticholinergic Therapy in Chronic Obstructive Pulmonary Disease

DENIS E. ODONNELL; MIU LAM; KATHERINE A. WEBB

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Spirometric Correlates of Improvement in Exercise Performance after Anticholinergic Therapy in Chronic Obstructive Pulmonary Disease

机译：肺功能检查与慢性阻塞性肺疾病抗胆碱能治疗后运动能力改善的相关性

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We wished to determine which resting spirometric parameters best reflect improvements in exercise tolerance and exertional dyspnea in response to acute high-dose anticholinergic therapy in advanced COPD. We studied 29 patients with stable COPD (FEV_1=40±2/100 predicted [/100pred]; mean±SEM) and moderate to severe chronic dyspnea. In a double-blined placebo-controlled cross-over study, pa- tiens performed spirometry and symptom-limited constant-load cycle exercise before and 1 h after receiving 500μg of nebulized ipratropium bromide (IB) or saline placebo.

机译：我们希望确定哪种静息肺活量参数最能反映出对晚期COPD的急性大剂量抗胆碱能疗法的反应，运动耐力和运动呼吸困难的改善。我们研究了29名稳定COPD（FEV_1 = 40±2/100预测[/ 100pred]；平均值±SEM）和中度至重度慢性呼吸困难的患者。在一项双盲安慰剂对照的交叉研究中，患者在接受500μg雾化的异丙托溴铵（IB）或生理盐水安慰剂之前和之后1小时进行了肺活量测定和症状受限的恒定负荷运动。

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《American journal of respiratory and critical care medicine》 |1999年第2期|p.542-549|共8页
作者
DENIS E. ODONNELL; MIU LAM; KATHERINE A. WEBB;
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收录信息美国《科学引文索引》(SCI);美国《化学文摘》(CA);
原文格式 PDF
正文语种 eng
中图分类呼吸系及胸部疾病;
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1. Improvements in Exercise Capacity and Dyspnoea by Inhaled Anticholinergic Drug in Elderly Patients with Chronic Obstructive Pulmonary Disease [J] . SHINJI TERAMOTO, YOSHINOSUKE FUKUCHI Age and Ageing . 1995,第4期

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2. Parasternal intercostal muscle ultrasound in chronic obstructive pulmonary disease correlates with spirometric severity [J] . Peter Wallbridge, Selina M. Parry, Sourav Das, Scientific reports. . 2018,第1期

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3. Spirometric Criteria for Chronic Obstructive Pulmonary Disease in Clinical Trials of Pharmacotherapy [J] . Fragoso Carlos A. Vaz, Gill Thomas M., Leo-Summers Linda S., COPD: Journal of Chronic Obstructive Pulmonary Disease . 2018,第1期

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4. A fuzzy rule-base model for classification of spirometric FVC graphs in chronical obstructive pulmonary diseases [C] . Uncu U., Koklukaya E., Gencsoy A., Engineering in Medicine and Biology Society, 2001. Proceedings of the 23rd Annual International Conference of the IEEE . 2001

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5. Health-related quality of life, functional status, and exercise tolerance of adults with chronic obstructive pulmonary disease following three treatment situations: Exercise alone, exercise with a lecture series, and exercise with activity training. [D] . Migliore, Anna. 2003

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8. Fuzzy Rule-Base Model for Classification of Spirometric FVC Graphs in Chronical Obstructive Pulmonary Diseases. [R] . Uncu, U., Koklukaya, E., Gencsoy, A., 2001

机译：慢性阻塞性肺疾病肺活量FVC图分类的模糊规则库模型。

Spirometric Correlates of Improvement in Exercise Performance after Anticholinergic Therapy in Chronic Obstructive Pulmonary Disease

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