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Detection of DNA hybridization using graphene-coated black phosphorus surface plasmon resonance sensor

机译:使用石墨烯涂层的黑磷表面等离子体共振传感器检测DNA杂交

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摘要

In this paper, graphene-coated black phosphorus at the metal surface for the detection of DNA hybridization event is numerically demonstrated. The strategy consists of placing the sensing medium on top of black phosphorus-graphene-coated SPR which interfaces with phosphate-buffered saline solution carrying single-stranded DNA. Upon hybridization with its complementary DNA, desorption of the nanostructures takes place and thus enables the sensitive detection of the DNA hybridization event. The proposed sensor exhibits a sensitivity (125 (omicron)/RIU), detection accuracy (0.95) and quality factor (13.62 RIU-1) for complementary DNA. In comparison with other reported papers, our suggested sensor provides much better performance. Thus, this label-free DNA detection platform should spur off new interest towards the use of black phosphorus-graphene-coated SPR interfaces.
机译:在本文中,在金属表面上涂有石墨烯的黑磷可用于DNA杂交事件的检测。该策略包括将传感介质放置在黑色磷-石墨烯涂层的SPR顶部,该涂层与携带单链DNA的磷酸盐缓冲盐溶液连接。与它的互补DNA杂交后,会发生纳米结构的解吸,从而能够敏感地检测到DNA杂交事件。所提出的传感器对互补DNA具有灵敏度(125(微米)/ RIU),检测精度(0.95)和品质因数(13.62 RIU-1)。与其他报告的论文相比,我们建议的传感器提供了更好的性能。因此,这种无标记的DNA检测平台应该激发对使用黑磷-石墨烯涂层的SPR接口的新兴趣。

著录项

  • 来源
    《Applied Physics》 |2018年第5期|394.1-394.11|共11页
  • 作者单位

    KIET Grp Inst, Dept Elect & Commun Engn, Ghaziabad 201206, UP, India;

    Inst Engn & Rural Technol, Dept Elect Engn, Allahabad, UP, India;

    Buldelkhand Inst Engn & Technol, Dept Elect & Commun Engn, Jhansi 284128, UP, India;

    Motilal Nehru Natl Inst Technol, Dept Elect & Commun Engn, Allahabad 211004, UP, India;

    Netaji Subhas Inst Technol NSIT, Dept Elect & Commun Engn, New Delhi 110078, India;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
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