High-performance polarization control modulated surface plasmon resonance sensor based on monolayer graphene/Au-NPs architecture for detection of DNA hybridization

Sun Yi; Cai Haoyuan; Qiao Xin; Wang Xiaoping

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High-performance polarization control modulated surface plasmon resonance sensor based on monolayer graphene/Au-NPs architecture for detection of DNA hybridization

机译：基于单层石墨烯/ AU-NPS架构进行DNA杂交检测的高性能偏振控制调制表面等离子体共振传感器

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摘要

A highly sensitive polarization control modulated plasmonic biosensor based on monolayer graphene/Au-NPs for direct detection of single-stranded DNA (ssDNA) hybridization is reported. The presence of monolayer graphene on gold film provides novel functionalized derivatives through pi-stacking interactions. In addition, the online assembly strategy via in situ monitoring between ssDNA and Au-NPs makes the binding easier and quantifiable. The use of strong plasmon-mediated energy confinements induces an approximately 30-fold intense field enhancement of the reflected light. The architecture exhibits a linear dynamic range of 10(-15) to 10(-7) M for the detection of target ssDNA. Moreover, the new biosensor can achieve an ultralow detection limit of 500 aM for 23-mer ssDNA via improved sensitivity to molecular bindings.

机译：报道了一种高敏感的偏振控制调制等离子传感器，其基于单层石墨烯/ AU-NPS直接检测单链DNA（SSDNA）杂交。通过PI堆叠相互作用，金膜上的单层石墨烯的存在提供了新型官能化衍生物。此外，在SSDNA和AU-NPS之间的原位监控的在线装配策略使得绑定更容易和可量化。使用强等离子介导的能量限制诱导反射光的大约30倍的强大的野外增强。该架构表现出10（-15）至10（-7）M的线性动态范围，用于检测目标SSDNA。此外，新的生物传感器可以通过改善对分子结合的敏感性来实现23-MESSDNA的UltraLow检测限。

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来源
《Measurement Science & Technology》 |2019年第12期|共9页
作者
Sun Yi; Cai Haoyuan; Qiao Xin; Wang Xiaoping;
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作者单位

Zhejiang Univ Ocean Coll Zhoushan 316021 Peoples R China;

Zhejiang Univ Ocean Coll Zhoushan 316021 Peoples R China;

Zhejiang Univ Ocean Coll Zhoushan 316021 Peoples R China;

Zhejiang Univ Ocean Coll Zhoushan 316021 Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类仪器、仪表;
关键词
plasmonic biosensor; DNA hybridization; graphene; Au nanoparticles; surface plasmon resonance;

机译：等离子体化生物传感器;DNA杂交;石墨烯;Au纳米粒子;表面等离子体共振;

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专利

1. High-performance polarization control modulated surface plasmon resonance sensor based on monolayer graphene/Au-NPs architecture for detection of DNA hybridization [J] . Sun Yi, Cai Haoyuan, Qiao Xin, Measurement Science & Technology . 2019,第12期

机译：基于单层石墨烯/ AU-NPS架构进行DNA杂交检测的高性能偏振控制调制表面等离子体共振传感器
2. Detection of DNA hybridization using graphene-coated black phosphorus surface plasmon resonance sensor [J] . Pal Sarika, Verma Alka, Raikwar S., Applied Physics . 2018,第5期

机译：使用石墨烯涂层的黑磷表面等离子体共振传感器检测DNA杂交
3. Design, optimization and critical analysis of graphene based surface plasmon resonance sensor for DNA hybridization [J] . Kumar Yagyesh, Mishra Rishi, Panwar Ekta, Optical and quantum electronics . 2019,第10期

机译：用于石墨烯杂交的石墨烯表面等离子体共振传感器的设计，优化和临界分析
4. Study on intensity-modulated surface plasmon resonance array sensor based on polarization control [C] . Sun Boshu, Wang Xiaoping, Huang Zihao 2010 3rd International Conference on Biomedical Engineering and Informatics . 2010

机译：基于极化控制的强度调制表面等离子体共振阵列传感器的研究
5. Detection of DNA hybridization to oligonucleotide arrays on gold surfaces using in situ surface plasmon resonance and fluorescence imaging techniques. [D] . Thiel, Andrew J. 1997

机译：使用原位表面等离子体共振和荧光成像技术检测与金表面寡核苷酸阵列的DNA杂交。
6. Electrostatic surface plasmon resonance: Direct electric field-induced hybridization and denaturation in monolayer nucleic acid films and label-free discrimination of base mismatches [O] . Richard J. Heaton, Alexander W. Peterson, Rosina M. Georgiadis 2001

机译：静电表面等离子体共振：直接电场诱导的单层核酸杂交和变性酸膜和碱基不匹配的无标记区分
7. Highly selective and sensitive detection of beta-agonists using a surface plasmon resonance sensor based on an alkanethiol monolayer functionalized on a Au surface [O] . Suherman, Morita Kinichi, Kawaguchi Toshikazu 2015

机译：使用基于在Au表面官能化的烷硫醇单分子层的表面等离子体激元共振传感器对β激动剂进行高选择性和灵敏的检测
8. Surface Plasmon Resonance Spectroscopy-Based Process Sensors [R] . McWhorter, S., Anderson, B. B., Zeigler, K. 2003

机译：基于表面等离子体共振光谱的过程传感器

High-performance polarization control modulated surface plasmon resonance sensor based on monolayer graphene/Au-NPs architecture for detection of DNA hybridization

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