High-resolution nuclear magnetic resonance applied to biophysics and molecular biology: highlights and challenges

Wider G.

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High-resolution nuclear magnetic resonance applied to biophysics and molecular biology: highlights and challenges

机译：高分辨率核磁共振应用于生物物理学和分子生物学：亮点与挑战

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The development and success of nuclear magnetic resonance (NMR) methods in biological research depend on high-field superconducting magnets with outstanding homogeneity and excellent long term stability. In biological and biomedical research NMR provides a means for studying crucial questions at a molecular level, including three-dimensional structures at atomic resolution, dynamics and folding as well as a drug discovery and drug design. Today, NMR with biological macromolecules in solution is one of the principal experimental techniques of structural biology, despite the fact that very large molecules cannot readily be investigated. With NMR methodological and biochemical advances this size limit could be extended several times.

机译：生物学研究中核磁共振（NMR）方法的发展和成功取决于具有出色均质性和出色长期稳定性的高场超导磁体。在生物和生物医学研究中，NMR提供了一种在分子水平上研究关键问题的方法，包括原子分辨率，动力学和折叠的三维结构以及药物发现和药物设计。如今，尽管无法对非常大的分子进行研究，但溶液中具有生物大分子的NMR已成为结构生物学的主要实验技术之一。随着NMR方法学和生化技术的进步，该尺寸限制可以扩展数倍。

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《IEEE Transactions on Applied Superconductivity》 |2002年第1期|p.740-745|共6页
作者
Wider G.;
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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);
原文格式 PDF
正文语种 eng
中图分类超导体、超导体材料;半导体技术;
关键词
NMR spectrometers; biological NMR; biological techniques; molecular biophysics; superconducting magnets; NMR methods; NMR spectrometer; TROSY; atomic resolution; biological macromolecules; biological research; biophysics; drug design; drug discovery; dynamics; folding;

机译：核磁共振波谱仪;生物核磁共振;生物学技术;分子生物物理学;超导磁体;核磁共振方法;核磁共振波谱仪;TROSY;原子分辨率;生物大分子;生物学研究;生物物理学;药物设计;药物发现;动力学;折叠;

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5. Biomolecular solid-state nuclear magnetic resonance methods for spectral assignment and high-resolution structure determination of proteins. [D] . Franks, William Trent. 2007

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6. Teaching high-resolution nuclear magnetic resonance to graduate students in biophysics. [O] . L Lerner, D A Horita 1993

机译：向生物物理研究生教授高分辨率核磁共振。
7. Teaching High-Resolution Nuclear Magnetic Resonance to Graduate Students in Biophysics [O] . Laura Lerner, David A. Horita 2008

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8. Magnetic Nuclear Resonance Applied to the Study of Amorphous Materials Resonance Magnetique Nucleaire Appliquee a l'Etude des Corps Amorphes. [R] . Szeftel, J. 1974

机译：磁核共振应用于非晶材料共振磁化核的研究应用于欧洲药剂师。

High-resolution nuclear magnetic resonance applied to biophysics and molecular biology: highlights and challenges

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