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Mussel-inspired tough hydrogels with self-repairing and tissue adhesion

机译:贻贝启发的坚韧水凝胶,具有自我修复和组织粘附力

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The mussel-inspired polymeric hydrogels have been attractively explored owing to their self-repairing or adhesive property when the catechol groups of dopamine could chelate metal ions. However, it was a challenge for self-repairing hydrogels owning high mechanical properties. Herein, a synergistic strategy was proposed by combining catechol-Fe3+ complexes and hydrophobic association. The resulting hydrogels exhibited seamless self-repairing behavior, tissue adhesion and high mechanical property. Moreover, the pH-dependent stoichiometry of catechol-Fe3+ and temperature-sensitive hydrophobic association endue hydrogels with pH/thermo responsive characteristics. Subsequently, the self-repairing rate and mechanical property of hydrogels were investigated at different pH and temperature. This bio-inspired strategy would build an avenue for designing and constructing a new generation of self-repairing, tissue-adhesive and tough hydrogel. (C) 2017 Elsevier B.V. All rights reserved.
机译:由于多巴胺的儿茶酚基团可以螯合金属离子,它们具有自我修复或粘合特性,因此受到了贻贝启发的聚合物水凝胶的研究。然而,这对于具有高机械性能的自修复水凝胶是一个挑战。在本文中,通过结合儿茶酚-Fe3 +配合物和疏水缔合提出了协同策略。所得水凝胶表现出无缝的自我修复行为,组织粘附性和高机械性能。此外,具有pH /热响应特性的邻苯二酚-Fe3 +和温度敏感的疏水缔合型水凝胶的pH依赖化学计量。随后,研究了在不同pH和温度下水凝胶的自修复率和力学性能。这种以生物为灵感的策略将为设计和构建新一代的自我修复,组织粘附和坚韧的水凝胶提供一条途径。 (C)2017 Elsevier B.V.保留所有权利。

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