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首页> 外文期刊>Applied Surface Science >beta-Cyclodextrin grafted polypyrrole magnetic nanocomposites toward the targeted delivery and controlled release of doxorubicin
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beta-Cyclodextrin grafted polypyrrole magnetic nanocomposites toward the targeted delivery and controlled release of doxorubicin

机译：β-环糊精接枝的聚吡咯磁性纳米复合材料对阿霉素的靶向递送和控制释放

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摘要

The Fe3O4@PPy-HA-beta-CD nanocomposites as the novel nanocarrier were prepared by grafting ethylenediamine derivative of beta-CD to the surface of polypyrrole-coated magnetic nanoparticles (Fe3O4@PPy) via using hyaluronan (HA) as the intermediate linker. HA was also the efficient target ligand for CD44. The as-prepared drug carrier was characterized by TEM, TGA, XRD, and VSM and used for the delivery of doxorubicin hydrochloride (DOX) with the high loading content of 447 mg/g. The multilayer Freundlich isotherm model was found to be a good fit for the loading of the drug carrier for DOX. Significant NIR-triggered release of DOX was observed in a weak acidic pH. And the release data in vitro was well described using the Retiger-Pepper kinetic model. Furthermore, MTT assay and confocal microscopy against Hep-G2 cells clearly illustrated that the drug carrier had no associated cytotoxicity and could easily enter the cells. The release and accumulation of DOX were observed in the cell nuclei. Thus, the DOX-loaded drug carrier killed the cancer cells efficaciously and minimized adverse side effects due to its target effect. These results suggested the as-prepared drug carrier would be of great potential for the controlled release and targeted delivery of DOX. (C) 2017 Elsevier B.V. All rights reserved.
机译：Fe3O4 @PPy-HA-β-CD纳米复合材料是通过使用透明质酸（HA）作为中间连接体将β-CD的乙二胺衍生物接枝到聚吡咯包覆的磁性纳米粒子（Fe3O4 @ PPy）的表面上而制备的。 HA还是CD44的有效靶标配体。所制备的药物载体通过TEM，TGA，XRD和VSM表征，并用于递送阿霉素盐酸盐（DOX），其高载量为447mg / g。发现多层Freundlich等温模型非常适合于DOX药物载体的装载。在弱酸性pH下观察到了NIR触发的DOX显着释放。使用Retiger-Pepper动力学模型很好地描述了体外释放数据。此外，针对Hep-G2细胞的MTT分析和共聚焦显微镜清楚地表明，该药物载体没有相关的细胞毒性，可以轻易进入细胞。在细胞核中观察到DOX的释放和积累。因此，装载有DOX的药物载体有效地杀死了癌细胞，并且由于其靶作用而使不良副作用最小化。这些结果表明，所制备的药物载体对于DOX的控释和靶向递送具有巨大的潜力。 （C）2017 Elsevier B.V.保留所有权利。

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  • 来源
    《Applied Surface Science》 |2018年第ptab期|1189-1198|共10页
  • 作者

    Hong Shasha; Li Zengbo; Li Chenzhong; Dong Chuan; Shuang Shaomin;

  • 作者单位

    Shanxi Univ, Inst Environm Sci, Coll Chem & Chem Engn, Taiyuan 030006, Shanxi, Peoples R China;

    Shanxi Univ, Inst Environm Sci, Coll Chem & Chem Engn, Taiyuan 030006, Shanxi, Peoples R China;

    Florida Int Univ, Dept Biomed Engn, Nanobioengn Bioelect Lab, Miami, FL 33199 USA;

    Shanxi Univ, Inst Environm Sci, Coll Chem & Chem Engn, Taiyuan 030006, Shanxi, Peoples R China;

    Shanxi Univ, Inst Environm Sci, Coll Chem & Chem Engn, Taiyuan 030006, Shanxi, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Magnetic nanocomposites; beta-Cyclodextrins; Targeted delivery; Controlled release;

    机译：磁性纳米复合材料;β-环糊精;靶向递送;控释;

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