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首页> 外文期刊>Arabian Journal for Science and Engineering >Synthesis, Antimicrobial Activity and Colorimetric Studies of Some New Bromo-quinazolinone Derivative as Potential Reactive Dyes
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Synthesis, Antimicrobial Activity and Colorimetric Studies of Some New Bromo-quinazolinone Derivative as Potential Reactive Dyes

机译：一些新的潜在潜在活性染料溴-喹唑啉酮衍生物的合成，抗菌活性和比色研究

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摘要

The objective of the current study was to introduce the quinazolinone molecule into a conventional reactive dye system. On this basis ten novel quinazolinone-based monochloro-s-triazine reactive dyes (7a-j) were rapidly and efficiently synthesized by coupling route of diazotized 3-{4'-[4"-amino-2",5"-dichlorob-enzyl]-2', 5/-dichlorophenyl}-6-bromo-2-phenylquinazolin-4(3H)-one (3) with a variety of m-nitro anilino cyanurated coupling components (6a-j). Their characterization was done using elemental analysis, UV-Vis, IR, ~1]H NMR and ~(13)C NMR spectroscopy. The solvatochromism was evaluated with respect to spectroscopic properties in organic solvents, viz., DMSO, DMF, methanol, acetic acid and chloroform. A detailed study of pharmacological screening (in vitro), solvatochromic effect, fastness properties, colorimetric data (L*, a*, b*, c*, H*, K/S) and thermogravimetric analysis was also investigated. These dyes showed generally moderate to very good light fastness and good to excellent washing and rubbing fastness properties and also showed good antimicrobial activity.
机译：当前研究的目的是将喹唑啉酮分子引入常规的活性染料体系中。在此基础上，通过重氮化的3- {4'-[4“-氨基-2”，5“ -dichlorob-偶合的偶联途径快速有效地合成了十种新颖的基于喹唑啉酮的单氯-s-三嗪活性染料（7a-j）。烯基] -2'，5 /-二氯苯基} -6-溴-2-苯基喹唑啉-4（3H）-一（3）与多种间硝基苯胺氰基化氰化偶合组分（6a-j），并进行了表征使用元素分析，UV-Vis，IR，〜1] H NMR和〜（13）C NMR光谱法对溶剂变色性在有机溶剂（即DMSO，DMF，甲醇，乙酸和氯仿）中的光谱性质进行了评估。还对药理学筛选（体外），溶剂变色作用，牢度特性，比色数据（L *，a *，b *，c *，H *，K / S）和热重分析进行了详细研究，这些染料表明通常具有中等至非常好的耐光性，以及良好至极好的耐洗和耐摩擦性，并且还显示出良好的抗菌活性。

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