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首页> 外文期刊>Arabian Journal for Science and Engineering >Photodynamic Inactivation of Staphylococcus epidermidis: Application of PEGylated Gold Nanoparticles
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Photodynamic Inactivation of Staphylococcus epidermidis: Application of PEGylated Gold Nanoparticles

机译：表皮葡萄球菌的光动力学灭活：聚乙二醇化金纳米粒子的应用。

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摘要

Nowadays, implant-related infections are considered as one of the major dangers for human health, and a novel method toablate the related pathogens is therefore crucial. In this paper, potentials of PEGylated gold nanoparticles to load methyleneblue and consequently enhance its effectiveness in photodynamic inactivation of Staphylococcus epidermidis (PTCC1114)were investigated. According to our experimental results, it was shown that PEGylated gold nanoparticles have the abilityto load and preserve optical properties of methylene blue. Our studies demonstrated that photodynamic inactivation of thebacteria in an in vitro model using a red laser (630 nm and 100 mW/cm~2) and methylene blue or methylene blue-PEGylatedgold nanoparticles showed a superiority for the PEGylated gold nanoparticles conjugated with methylene blue. In fact, conjugationof MB with the PEGylated gold nanoparticles avoids dimer formation through preventing direct contact betweenMB and cellular or plasma components. Based on the results of this paper, PEGylated gold nanoparticles are proposed toimprove the photodynamic inactivation of implant-related infections.
机译：如今，与植入物有关的感染被视为对人类健康的主要危险之一，因此消灭相关病原体的新方法至关重要。本文研究了聚乙二醇化金纳米颗粒负载亚甲基蓝并因此增强其在表皮葡萄球菌（PTCC1114）光动力灭活中的有效性的潜力。根据我们的实验结果，表明聚乙二醇化的金纳米颗粒具有负载和保持亚甲基蓝的光学性质的能力。我们的研究表明，在体外模型中使用红色激光（630 nm和100 mW / cm〜2）和亚甲基蓝或亚甲基蓝-聚乙二醇化金纳米粒子对细菌进行光动力学灭活，显示出与亚甲基蓝共轭的聚乙二醇化金纳米粒子具有优越性。实际上，MB与聚乙二醇化金纳米颗粒的共轭可通过防止MB与细胞或血浆成分之间的直接接触来避免二聚体的形成。基于本文的结果，提出了聚乙二醇化金纳米粒子，以改善植入物相关感染的光动力学失活。

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