...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Archives of Pharmacal Research >Syringin from stem bark of Fraxinus rhynchophylla protects Aβ(25–35)-induced toxicity in neuronal cells
【24h】

Syringin from stem bark of Fraxinus rhynchophylla protects Aβ(25–35)-induced toxicity in neuronal cells

机译：水曲柳茎皮中的丁香香精素可保护Aβ（25-35）诱导的神经元细胞毒性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The medicinal herb Jinpi, derived from the dried stem barks of Fraxinus rhynchophylla belonging to Oleaceae is widely used as a variety of Korean folk remedies for anti-inflammatory, febricide, antidiarrhea, and antileukorrhea diseases. In the course of screening antidementia agents from natural products, F. rhynchophylla showed significant inhibitory activity toward Aβ(25–35)-induced neuronal cell death. An active principle was isolated and identified as syringin. When the neuroblastoma cells were exposed to 50 μM Aβ(25–35), 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction rate (survival rate) decreased to 60.21 ± 2.16% over control while syringin treated ones recovered cell viability up to 79.12 ± 1.39% at 20 μM. In addition, 20 μM syringin almost completely removed Aβ(25–35)-induced reactive oxygen species. The neuroprotective effect of syringin seemed to be originated from the reduction of apoptosis since decrease in caspase-3 activity and expression, reduction in cleaved PARP, and DNA fragmentation were observed. These results suggest that F. rhynchophylla and syringin are expected to be useful for preventing Aβ(25–35)-induced neuronal cell damage.
机译：药用植物金皮（Jinpi）源自欧亚菊科植物白蜡树的干茎皮，被广泛用作抗炎，除草剂，止泻和抗白带病的各种韩国民间疗法。在从天然产物中筛选抗痴呆剂的过程中，F。rhynchophylla对Aβ（25-35）诱导的神经元细胞死亡具有明显的抑制活性。分离出有效成分并鉴定为丁香精。当神经母细胞瘤细胞暴露于50μMAβ（25-35）时，3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑溴化物（MTT）降低率（存活率）速率比对照降低至60.21±2.16％，而丁香素处理的细胞在20μM时可恢复至79.12±1.39％的细胞活力。此外，20μM丁香香精素几乎完全去除了Aβ（25–35）诱导的活性氧。 syringin的神经保护作用似乎起源于凋亡的减少，因为观察到caspase-3活性和表达的减少，PARP的裂解和DNA片段的减少。这些结果表明，毛花镰刀菌和丁香香精素有望用于预防Aβ（25-35）诱导的神经元细胞损伤。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号