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首页> 外文期刊>Archives of Women's Mental Health >Higher DHEA-S (dehydroepiandrosterone sulfate) levels are associated with depressive symptoms during the menopausal transition: results from the PENN Ovarian Aging Study
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Higher DHEA-S (dehydroepiandrosterone sulfate) levels are associated with depressive symptoms during the menopausal transition: results from the PENN Ovarian Aging Study

机译：DHEA-S（硫酸脱氢表雄酮硫酸盐）水平升高与更年期过渡期间的抑郁症状相关：PENN卵巢衰老研究的结果

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The influence of sex hormones on mood during the menopausal transition has been the subject of ongoing investigation. Because dehydroepiandrosterone sulfate (DHEA-S) has been associated with several indicators of healthy aging, we conducted a population-based study of midlife women to determine the relationship between DHEA-S levels and depressive symptoms and major depression during the transition through menopause. Unexpectedly, the original report revealed a positive correlation between DHEA-S levels and depressive symptoms at baseline. The cohort was studied over 11 years to determine whether the positive association between DHEA-S levels and depression persists through the menopausal transition. We conducted a longitudinal cohort study with 11 assessments during an 11-year interval in Philadelphia, Pennsylvania, using a randomly identified, population-based sample of 436 African American and Caucasian premenopausal women aged 35 to 47 years at enrollment. For outcome measures, we used the Center for Epidemiologic Studies Depression Scale and standardized diagnosis of major depression. In a multivariable model, DHEA-S levels were positively associated with depressive symptoms when adjusted for age, menopausal stage, race, smoking status, and body mass index. There was no association between DHEA-S levels and a diagnosis of major depression. DHEA-S levels were positively associated with depressive symptoms through the menopausal transition. No association with major depression was apparent during the menopausal transition, but results may have limited power due to low prevalence of major depression in this cohort. These findings suggest that taking DHEA supplements may increase depressive symptoms for some women, and women and their physicians should be cautious about instituting DHEA replacement therapy during the menopausal transition.
机译：绝经过渡期性激素对情绪的影响一直是研究的主题。由于硫酸脱氢表雄酮硫酸盐（DHEA-S）与健康衰老的多项指标有关，因此我们对中年妇女进行了一项基于人群的研究，以确定DHEA-S水平与绝经过渡期间抑郁症状和严重抑郁之间的关系。出乎意料的是，原始报告显示DHEA-S水平与基线抑郁症状之间呈正相关。对该队列进行了长达11年的研究，以确定DHEA-S水平与抑郁之间的正向联系是否在绝经期过渡期间持续存在。我们在宾夕法尼亚州的费城进行了为期11年的纵向队列研究，每11年进行一次评估，该研究使用了随机抽取的基于人群的样本，样本为436名年龄在35至47岁之间的非洲裔美国人和白人绝经前妇女。对于结果测量，我们使用了流行病学研究中心抑郁量表和重度抑郁的标准化诊断。在多变量模型中，按年龄，更年期，种族，吸烟状况和体重指数进行调整后，DHEA-S水平与抑郁症状呈正相关。 DHEA-S水平与重度抑郁症的诊断之间没有关联。 DHEA-S水平通过更年期过渡与抑郁症状呈正相关。在绝经期过渡期没有明显的与重度抑郁症的关联，但是由于该人群中重度抑郁症的患病率较低，因此结果的功效可能有限。这些发现表明，服用DHEA补充剂可能会增加某些女性的抑郁症状，而且女性及其医生在绝经期过渡期应谨慎选择DHEA替代疗法。

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