Inherently Distorted Heme as a Novel Tool for Myoglobin-Based Oxygen Carrier

Saburo Neya; Akira T. Kawaguchi

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Inherently Distorted Heme as a Novel Tool for Myoglobin-Based Oxygen Carrier

机译：固有变形的血红素作为基于肌红蛋白的氧气载体的新型工具

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The two types of artificial myoglobins (Mbs) containing inherently distorted -ethyl-2,4-dimethyldeuteroheme and undistorted 2,4-dimethyldeuteroheme were prepared to examine the influence of nonplanar heme deformation on the reactivity of Mb. In ferrous deoxy proteins, the paramagnetic proton nuclear magnetic resonance spectra showed that the deformed heme caused a 3.2-ppm lower-field shift of the proximal histidine signal, indicating a larger iron displacement from the heme plane upon the nonplanar deformation. The Mb with the nonplanar heme exhibited a markedly lower oxygen affinity as compared with the Mb containing the planar heme. The result suggests the utility of heme distortion to design the Mb-based oxygen carrier.?

机译：制备了包含固有变形的-乙基-2,4-二甲基氘血红素和未变形的2,4-二甲基氘血红素的两种类型的人工肌球蛋白（Mbs），以检验非平面血红素变形对Mb反应性的影响。在亚铁脱氧蛋白中，顺磁质子核磁共振波谱显示，变形的血红素引起近端组氨酸信号的3.2 ppm下场位移，表明非平面变形时铁从血红素平面的位移更大。与含有平面血红素的Mb相比，具有非平面血红素的Mb表现出明显更低的氧亲和力。结果表明血红素畸变可用于设计基于Mb的氧气载体。

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来源
《Artificial Organs》 |2012年第2期|220-223|共4页
作者
Saburo Neya; Akira T. Kawaguchi;
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作者单位

Department of Physical Chemistry Graduate School of Pharmaceutical Sciences Chiba University Inage-Yayoi Chiba;

School of Medicine Tokai University Isehara Kanagawa Japan;

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原文格式 PDF
正文语种 eng
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关键词
Myoglobin; Built-in heme distortion; Iron movement; Artificial oxygen carrier;

机译：肌红蛋白;内置血红素畸变;铁运动;人工氧气载体;

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专利

1. Inherently Distorted Heme as a Novel Tool for Myoglobin-Based Oxygen Carrier [J] . NeyaS., KawaguchiA.T. Artificial Organs . 2012,第2期

机译：固有变形的血红素作为基于肌红蛋白的氧气载体的新型工具
2. Usefulness of myoglobin containing cobalt heme cofactor in designing a myoglobin-based artificial oxygen carrier [J] . NeyaS., YonetaniT., KawaguchiA.T. Artificial Organs . 2014,第8期

机译：含肌红蛋白的钴血红素辅因子在设计基于肌红蛋白的人工氧气载体中的有用性
3. Fixation of Zinc(II) Ion to Dioxygen in a Highly Deformed Porphyrin: Implications for the Oxygen Carrier Mechanism of Distorted Heme [J] . Zhou Zaichun, Zhou Xiaochun, Liu Qiuhua, Organic letters . 2015,第16期

机译：锌（II）离子固定到高度变形的卟啉中的双氧：变形血红素的氧气载体机制的意义。
4. Heme Binding Analysis of Heme Regulatory Motifs of Rat Heme Oxygenase-2 [C] . Tomomi Ueda, Shinya Koga, Yuichiro Higashimoto Japanese peptide symposium . 2010

机译：大鼠血红素氧氨基氨基酶-2血红素调节基序血红素结合分析
5. Part I. Magnetic circular dichroism studies of cytochrome c peroxidase from yeast: Investigations of the active site heme coordination sphere through comparison with horseradish peroxidase and myoglobin. Part II. Examination of the heme active site coordination structure of the cavity mutants of myoglobin (H93G), cytochrome c peroxidase (H175G), and heme oxygenase (H25A) and structural investigation of thiolate-ligated cytochrome c peroxidase in the H17C/D235L double mutant. [D] . Pond, Alycen Easterling. 1999

机译：第一部分。酵母中细胞色素C过氧化物酶的磁性圆二色性研究：通过与辣根过氧化物酶和肌红蛋白的比较，研究了活性部位血红素配位域。第二部分检查肌红蛋白（H93G），细胞色素c过氧化物酶（H175G）和血红素加氧酶（H25A）的空腔突变体的血红素活性位点配位结构，以及H17C / D235L双突变体中硫醇盐连接的细胞色素c过氧化物酶的结构研究。
6. Factors That Distort the Heme Structure in Heme-Nitric Oxide/OXygen-Binding (H-NOX) Protein Domains. A Theoretical Study [O] . Meng-Sheng Liao, Ming-Ju Huang, John D. Watts -1

机译：血液一氧化氮/氧合（H-NOx）蛋白结构域扭曲血红素结构的因素。一个理论研究
7. Factors that distort the heme structure in Heme-Nitric Oxide/OXygen-Binding (H-NOX) protein domains. A theoretical study [O] . Meng-Sheng Liao, Ming-Ju Huang, John D. Watts 2013

机译：血液一氧化氮/氧合（H-NOx）蛋白结构域扭曲血红素结构的因素。一个理论研究

Inherently Distorted Heme as a Novel Tool for Myoglobin-Based Oxygen Carrier

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