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Comparing cortisol, stress, and sensory sensitivity in children with autism

机译:比较自闭症儿童的皮质醇,压力和感觉敏感性

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摘要

Previously we reported that children with autism show significant variability in cortisol. The current investigation was designed to extend these findings by exploring plausible relationships between cortisol and psychological measures of stress and sensory functioning. Salivary cortisol values for diurnal rhythms and response to stress in children with and without autism were compared to parent-report measures of child stress, the Stress Survey Schedule (SSS), sensory functioning, Short Sensory Profile (SSP), and Parenting Stress Index. In autism, a negative relationship between morning cortisol and the SSS revealed that higher observed symptoms of stress were related to lower cortisol. Lower cortisol is seen in conditions of chronic stress and in social situations characterized by unstable social relationships. Sensory sensitivity painted a more complicated picture, in that some aspects of SSP were associated with higher while others were associated with lower cortisol. We propose that increased sensory sensitivity may enhance the autistic child's susceptibility to the influence of zeitgeibers reflected in variable cortisol secretion. Evening cortisol was positively associated with SSS such that the higher the level of evening cortisol, the higher the child's parent-reported daily stress, especially to changes, such as in daily routine. Regarding the response to stress, the psychological and parent variables did not differentiate the groups; rather, discrete subgroups of cortisol responders and nonresponders were revealed in both the autism and neurotypical children. The results support a complex interplay between physiological and behavioral stress and sensory sensitivity in autism and plausible developmental factors influencing stress reactivity across the groups.
机译:先前我们报道自闭症儿童的皮质醇表现出明显的变异性。当前的研究旨在通过探索皮质醇与压力和感觉功能的心理测量之间的合理联系来扩展这些发现。将有自闭症和无自闭症儿童的昼夜节律和对压力的反应的唾液皮质醇值与父母对儿童压力,压力调查时间表(SSS),感觉功能,短感官(SSP)和父母压力指数的报告进行比较。在自闭症中,早晨皮质醇和SSS之间的负相关关系表明,观察到的较高的压力症状与较低的皮质醇有关。在慢性压力和以不稳定的社会关系为特征的社会环境中,皮质醇含量较低。感觉敏感性描绘了一个更为复杂的图景,因为SSP的某些方面与较高的水平相关,而另一些方面与较低的皮质醇相关。我们建议增加感官敏感性可以增强自闭症儿童对皮质醇分泌可变所反映的Zeitgeibers影响的敏感性。晚上皮质醇与SSS呈正相关,因此晚上皮质醇水平越高,孩子父母报告的每日压力就越高,尤其是对于日常变化等方面的压力。关于对压力的反应,心理变量和父母变量并没有区分群体。相反,在自闭症和神经性典型儿童中,皮质醇反应者和无反应者的离散亚组被发现。结果支持自闭症的生理和行为压力与感官敏感性之间的复杂相互作用,以及影响各组间压力反应性的可能的发育因素。

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  • 来源
    《Autism Research》 |2009年第1期|39-49|共11页
  • 作者单位

    Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, California|The M.I.N.D. Institute, University of California, Davis, Sacramento, California;

    Graduate Group in Epidemiology, University of California, Davis, Sacramento, California;

    Department of Psychiatry and Behavioral Sciences, University of California, Davis, Sacramento, California;

    Department of Psychology, University of California, Davis, Sacramento, California;

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