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Novel SNPs of the Bovine PRLR Gene Associated with Milk Production Traits

机译：牛PRLR基因与牛奶生产性状相关的新型单核苷酸多态性。

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The single nucleotide polymorphisms (SNPs) within exon 10 of the prolactin receptor gene (PRLR) were detected in Chinese Holstein cows using polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) and DNA sequencing methods, and their genetic effects on milk production traits were evaluated in this study. Two newly detected SNPs (g.9206G→A and g.9681C→T) caused amino acid variations E378K and A536V, respectively, which were then preliminarily predicted at the topological level. Statistical results indicated that the two SNPs were significantly associated with milk yields, and cows with the combined genotype GGCC showed superior milk performance. A putative phosphorylation site was identified at residue 378K ([ST]-×-[RK]), which offers a partial explanation for the associations. These results suggest that the two novel SNPs within exon 10 of the PRLR gene associated with milk production traits are useful genetic markers in a selection program for Holstein dairy cattle.
机译：应用聚合酶链反应-单链构象多态性（PCR-SSCP）和DNA测序方法检测中国荷斯坦奶牛泌乳素受体基因（PRLR）第10外显子的单核苷酸多态性（SNP）。本研究评估了生产特性。两个新检测到的SNP（g.9206G→A和g.9681C→T）分别引起氨基酸变异E378K和A536V，然后在拓扑水平上对其进行了初步预测。统计结果表明，这两个SNP与产奶量显着相关，基因型GGCC组合的奶牛表现出更好的产奶性能。在残基378K（[ST] -x- [RK]）处鉴定出一个推测的磷酸化位点，这为该结合提供了部分解释。这些结果表明，PRLR基因第10外显子中与乳汁生产性状相关的两个新SNP在荷斯坦奶牛的选择程序中是有用的遗传标记。

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