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首页> 外文期刊>Biochemical Genetics >Genetic Polymorphisms of the CACNA2D1 Gene and Their Association with Carcass and Meat Quality Traits in Cattle
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Genetic Polymorphisms of the CACNA2D1 Gene and Their Association with Carcass and Meat Quality Traits in Cattle

机译：CACNA2D1基因的遗传多态性及其与牛Car体和肉质性状的关系

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摘要

The objective of this study was to identify genetic polymorphisms of the CACNA2D1 gene and to analyze associations between SNPs and carcass and meat quality traits in cattle. Through PCR-RFLP and DNA sequencing methods, a new allelic variant corresponding to the A → G mutation (aspartic to glycine amino acid replacement) of the bovine CACNA2D1 gene was detected. Two alleles and three genotypes (AA, AG, and GG) were defined. Genetic character indicated that the A526745G locus showed moderate polymorphism and was in Hardy–Weinberg equilibrium. Gene-specific SNP marker association analysis showed that the A526745G mutant was significantly associated with carcass weight, dressing percentage, meat percentage, and backfat thickness. The results add new evidence that CACNA2D1 is an important candidate gene for the selection of carcass and meat quality traits in the cattle industry.
机译：这项研究的目的是确定CACNA2D1基因的遗传多态性，并分析SNP与cas体和牛肉品质性状之间的关联。通过PCR-RFLP和DNA测序方法，检测到与牛CACNA2D1基因的A→G突变（天冬氨酸取代甘氨酸氨基酸）相对应的新等位基因变体。定义了两个等位基因和三个基因型（AA，AG和GG）。遗传特征表明，A526745G基因座表现出中等多态性，处于Hardy-Weinberg平衡状态。基因特异性SNP标记关联分析表明，A526745G突变体与car体重量，敷料百分比，肉类百分比和后脂肪厚度显着相关。结果提供了新的证据，表明CACNA2D1是选择牛业industry体和肉质性状的重要候选基因。

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