Characterization of the Terminal Activation Step Catalyzed by Oxygenase CmmOIV of the Chromomycin Biosynthetic Pathway from Streptomyces griseus

Mary A. Bosserman Ana B. Florez Khaled A. Shaaban Alfredo F. Brana Jose A. Salas Carmen Mendez and Jurgen Rohr

首页> 外文期刊>Biochemistry >Characterization of the Terminal Activation Step Catalyzed by Oxygenase CmmOIV of the Chromomycin Biosynthetic Pathway from Streptomyces griseus

【24h】

Characterization of the Terminal Activation Step Catalyzed by Oxygenase CmmOIV of the Chromomycin Biosynthetic Pathway from Streptomyces griseus

机译：灰霉素链霉菌生物合成途径的加氧酶CmmOIV催化的末端活化步骤的表征

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Inactivation and initial interrogation of key oxygenase CmmOIV of the biosynthetic pathway ofnchromomycin A3 in Streptomyces griseus ssp. griseus revealed that a completely methylated and acetylatednprechromomycin is the preferred substrate of this enzyme. This suggests that the three sugar decoration reactions,ntwo O-acetylations and an O-methylation, which were previously believed to occur as the final steps ofnchromomycin A3 biosynthesis, indeed take place prior to the CmmOIV reaction. Upon inactivation of CmmOIV,nfour new compounds accumulated; the fully decorated prechromomycin and its incompletely acetylated precursornalong with a diketoprechromomycin-type compound were fully characterized and assayed with CmmOIV.

机译：灰链霉菌属菌种nchromomycin A3生物合成途径关键氧合酶CmmOIV的失活和初步询问。 griseus透露，完全甲基化和乙酰化的前原霉素是该酶的首选底物。这表明以前认为是嗜铬霉素A3生物合成的最后步骤发生的三个糖修饰反应，即两个O-乙酰化和一个O-甲基化，确实发生在CmmOIV反应之前。 CmmOIV灭活后，累积了四个新化合物；用CmmOIV对完全修饰的前生色霉素及其不完全乙酰化的前苯二酚和二酮泛生色霉素类化合物进行了鉴定和分析。

著录项

来源
《Biochemistry》 |2011年第8期|p.1421-1428|共8页
作者
Mary A. Bosserman Ana B. Florez Khaled A. Shaaban Alfredo F. Brana Jose A. Salas Carmen Mendez and Jurgen Rohr;
展开▼
作者单位

‡Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 789 South Limestone Street, Lexington,Kentucky 40536-0596, United States, and §Departamento de Biologı ´a Funcional e Instituto Universitario de Oncologı ´a del Principadode Asturias (IUOPA), Universidad de Oviedo, 33006 Oviedo, Spain;

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类
关键词

相似文献

外文文献
中文文献
专利

1. Characterization of the Terminal Activation Step Catalyzed by Oxygenase CmmOIV of the Chromomycin Biosynthetic Pathway from Streptomyces griseus [J] . Bosserman MA, Florez AB, Shaaban KA, Biochemistry . 2011,第8期

机译：从链霉素Griseus的色素生物霉素生物合成途径催化的末端活化步骤的表征
2. Characterization of New Class III Lantibiotics-Erythreapeptin, Avermipeptin and Griseopeptin from Saccharopolyspora erythraea, Streptomyces avermitilis and Streptomyces griseus Demonstrates Stepwise N-Terminal Leader Processing [J] . V?ller G.H., Krawczyk J.M., Pesic A., Chembiochem: A European journal of chemical biology . 2012,第8期

机译：新型III类Lantibiotics-exerythepeptin，Avermipeptin和Griseopeptin的特征来自Saccharopolyspora erythraea，Streptomyces Avermitilis和Streptomyces Griseus逐步进行N-终端领导加工
3. 182 POSTER In vitro and in vivo antitumor activity of novel aureolic acid analogues generated by metabolic engineering of the biosynthetic pathways in Streptomyces argillaceus and treptomyces griseus subsp. griseus [J] . A.Malek, L.E.Nú?ez, N.Menéndez, European Journal of Cancer Supplements . 2008,第12期

机译：182海报新型链霉菌和灰链霉菌亚种生物合成途径的代谢工程产生的新型金酸类似物的体外和体内抗肿瘤活性。灰绿色
4. Synthesis and Characterization of Activated Carbon from White Lotus via Single Step Chemical Activation [C] . Jeyashelly Andas, Muhammad Dzulfiqar Midon International Conference on Chemical Materials and Process . 2017

机译：单步化学活化的白莲花活性炭的合成与表征
5. Natural products biosynthesis: I. Geosmin biosynthesis in Streptomyces coelicolor A3(2) and Nostoc punctiforme PCC 73102. II. Pentalenolactone biosynthetic pathway in Streptomyces avermitilis. [D] . Jiang, Jiaoyang. 2009

机译：天然产物的生物合成：I. coelicolor链霉菌A3（2）和点状诺氏菌PCC 73102中的土臭素生物合成。阿维链霉菌中的戊烯戊内酯生物合成途径。
6. Characterization of the Terminal Activation Step Catalyzed by Oxygenase CmmOIV of the Chromomycin Biosynthetic Pathway from Streptomyces griseus [O] . Mary A. Bosserman, Ana B. Flórez, Khaled A. Shaaban, -1

机译：从灰色链霉菌由色霉素生物合成途径的加氧酶催化CmmOIV终端激活步骤的表征
7. Characterization of the Terminal Activation Step Catalyzed by Oxygenase CmmOIV of the Chromomycin Biosynthetic Pathway from Streptomyces griseus [O] . Bosserman, Mary A., Flórez García, Ana Belén, Shaaban, Khaled A., 2011

机译：灰霉素链霉菌生物合成途径的加氧酶CmmOIV催化的末端活化步骤的表征

Characterization of the Terminal Activation Step Catalyzed by Oxygenase CmmOIV of the Chromomycin Biosynthetic Pathway from Streptomyces griseus

摘要

著录项

相似文献

相关主题

期刊订阅