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首页> 外文期刊>Biofouling >In vitro anti-biofilm efficacy of sanguinarine against carbapenem-resistant Serratia marcescens
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In vitro anti-biofilm efficacy of sanguinarine against carbapenem-resistant Serratia marcescens

机译：血红素内的体外抗生物膜效果对耐鲤鱼抗性的静脉曲张

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摘要

Sanguinarine, a plant-derived benzophenanthridine alkaloid, was studied in terms of its anti-biofilm effects against carbapenem-resistant Serratia marcescens (CRSM). Minimum inhibitory concentrations (MICs) and cell membrane integrity were measured to investigate the antimicrobial mechanism of sanguinarine. Additionally, the extent of biofilm formation by CRSM exposed to sanguinarine was measured by crystal violet staining and visualized via field emission scanning electron microscopy and confocal laser scanning microscopy. Sanguinarine displayed moderate activity against CRSM, with a MIC90 of 32 mu g ml(-1). Moreover, cell membrane integrity was severely disrupted by sanguinarine at 64 mu g ml(-1), and biofilm formation was sharply inhibited at 32 mu g ml(-1). The minimum biofilm eradication concentration was 512 mu g ml(-1) against mature CRSM biofilms. The overall results suggest that sanguinarine is a potential anti-biofilm agent that can be explored to treat CRSM infections.
机译：植物衍生的苯并苯蒽氨氨酸生物碱，在抗生物膜抗性抗肉豆蔻抗性Sercescens（CRSM）方面研究了植物衍生的苯并苯蒽啶生物碱。 测量最小抑制浓度（MICS）和细胞膜完整性，以研究血红素的抗微生物机制。 另外，通过晶体紫染色和通过现场发射扫描电子显微镜和共聚焦激光扫描显微镜观察，通过晶体染色和可视化的CRSM的生物膜形成程度。 Sanguinarine针对CRSM显示适度的活动，MIC90为32μgml（-1）。 此外，在64μgmm（-1）下，血征严重破坏细胞膜完整性，并且在32μgmm（-1）下急剧抑制生物膜形成。 最小生物膜根除浓度为512μgml（-1）针对成熟Crsm生物膜。 总体结果表明，血红素是一种潜在的抗生物膜剂，可以探索治疗CRSM感染。

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  • 来源
    《Biofouling》 |2021年第4期|341-351|共11页
  • 作者

    Fu Yuting; Liu Wanting; Liu Miao; Zhang Jianing; Yang Min; Wang Ting; Qian Weidong;

  • 作者单位

    Shaanxi Univ Sci & Technol Sch Food & Biol Engn Xian Peoples R China;

    Shaanxi Univ Sci & Technol Sch Food & Biol Engn Xian Peoples R China;

    Shaanxi Univ Sci & Technol Sch Food & Biol Engn Xian Peoples R China;

    Shaanxi Univ Sci & Technol Sch Food & Biol Engn Xian Peoples R China;

    Shaanxi Univ Sci & Technol Sch Food & Biol Engn Xian Peoples R China;

    Shaanxi Univ Sci & Technol Sch Food & Biol Engn Xian Peoples R China;

    Shaanxi Univ Sci & Technol Sch Food & Biol Engn Xian Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Sanguinarine; carbapenem-resistant Serratia marcescens; antimicrobial; antibiofilm;

    机译：Sanguinarine;耐药抗性Serratia marcescens;抗菌剂;抗菌剂;抗血管;

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