Physiological Effects of Selank and Its Fragments

Koroleva S. V.; Mjasoedov N. F.

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Physiological Effects of Selank and Its Fragments

机译：Selank及其片段的生理效应

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-The development of Selank based on the natural regulatory peptide tuftsin allowed combining the native bioactivity of the molecule with the design engineering of certain physiological functions. Based on a summary of the experimental and clinical data, a comparative analysis of the structural and functional regularities of the effects of Selank and its fragments was performed. The qualitative and quantitative characteristics of correctional processes (anxiolytic, cognitive, immunostimulatory, anti-ulcer, etc.), triggered by the peptide drug and its analogues, are summarized into a single scheme. It is assumed that the Selank effect on the network of cascade processes of peptides and mediators is carried out through enkephalin, the key player of this system.

机译：-基于天然调节肽簇蛋白的Selank的开发使该分子的天然生物活性与某些生理功能的设计工程相结合。在总结实验和临床数据的基础上，对Selank及其片段的作用的结构和功能规律进行了比较分析。由肽药物及其类似物引发的校正过程（抗焦虑，认知，免疫刺激，抗溃疡等）的定性和定量特征被汇总到一个单一的方案中。假定通过该系统的关键参与者脑啡肽对肽和介体的级联过程的网络产生塞兰克效应。

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《Biology Bulletin》 |2019年第4期|407-414|共8页
作者
Koroleva S. V.; Mjasoedov N. F.;
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Russian Acad Sci Inst Mol Genet Moscow 123182 Russia;

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Physiological Effects of Selank and Its Fragments

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