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Involvement of Recovery Processes in the Effects of Radioprotectors at the Cellular and Organismal Levels

机译:恢复过程参与辐射防护剂在细胞和有机体水平的影响

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摘要

A correlation between the effectiveness of the radioprotective action of cysteamine with the radiosensitivity of cells and their ability to recover from radiation damage was demonstrated for diploid yeast cells of S. cerevisiae. To demonstrate the involvement of the recovery processes in the mechanism for radioprotective action of the T1023 compound in animals, data on the survival of clonogenic bone marrow cells of mice exposed to ionizing radiation are presented. It is shown that the radioprotective effect of this compound can be realized not only at the physicochemical stage of formation of radiation damage due to a decrease in the oxygen content in tissues but also due to the post-radiation cell recovery at the biochemical stage. This is confirmed by the presence of the sigmoid part of the dose-response curve in the region of low doses of ionizing radiation.
机译:对于酿酒酵母的二倍体酵母细胞,对细胞辐射敏感性与细胞辐射敏感性的射频作用与细胞放射损伤的能力之间的相关性。为了证明恢复过程在动物中的T1023化合物在动物的辐射防护作用机制中的累积,提出了暴露于电离辐射的小鼠的克隆骨髓细胞存活的数据。结果表明,由于组织中的氧含量的降低,该化合物的放射性保护作用不仅是由于组织中的氧含量的降低而形成的辐射损伤的物理化学阶段,而且因此是由于生物化学阶段的辐射后细胞恢复。这是通过在低剂量电离辐射区域中存在的剂量 - 响应曲线的矩形部分来确认。

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  • 来源
    《Biology Bulletin》 |2019年第12期|1619-1624|共6页
  • 作者单位

    Minist Hlth Russian Federat Tsyb Med Radiol Res Ctr Branch Natl Med Res Radiol Ctr Obninsk Russia;

    Minist Hlth Russian Federat Tsyb Med Radiol Res Ctr Branch Natl Med Res Radiol Ctr Obninsk Russia;

    Minist Hlth Russian Federat Tsyb Med Radiol Res Ctr Branch Natl Med Res Radiol Ctr Obninsk Russia;

    Minist Hlth Russian Federat Tsyb Med Radiol Res Ctr Branch Natl Med Res Radiol Ctr Obninsk Russia;

    Minist Hlth Russian Federat Tsyb Med Radiol Res Ctr Branch Natl Med Res Radiol Ctr Obninsk Russia;

    Minist Hlth Russian Federat Tsyb Med Radiol Res Ctr Branch Natl Med Res Radiol Ctr Obninsk Russia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    radioprotective action; cysteamine; T1023; sublethal damage; post-radiation recovery;

    机译:辐射保护作用;囊麦胺;T1023;亚致死损伤;后辐射回收;

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