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The Mechanism of Suppression of Chronic Hepatitis C Infection by the Medicine Stimforte

机译：药物刺激抑制慢性丙型肝炎感染的机制

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The effect of the drug Stimforte on infection by the Hepatitis C virus (HCV) has been studied. Stimforte partially inhibits HCV infection at a dose of 100 mu g/mouse and almost completely at a dose of 300 mu g/mouse within 24 h after administration of the drug. The mice sera resulting after 24 h in the presence of 100 and 300 mu g/mouse of Stimforte effectively inhibit the production of HCV. Doses of 150, 200, and 250 mu g/mouse are not effective. Stimulation of interferon-beta (IFN-beta) production is only observed at doses of 100 and 300 mu g/mouse, which explains well the neutralizing capacity of the sera. The amount of IFN-gamma also correlates well with the antiviral activity and neutralizing activity of mice sera. The drug practically does not stimulate production of IFN-lambda. Thus, the neutralizing activity of sera and the antiviral activity are largely determined by the 1st and 2nd IFN groups.
机译：研究了药物甜味对丙型肝炎病毒（HCV）感染的影响。 Stimforte以100μg/小鼠的剂量部分抑制HCV感染，并且在给药后24小时内几乎完全以300μg/小鼠的剂量为300μg/小鼠。在100至300μg/鼠的刺激的情况下，24小时得到的小鼠血清有效抑制HCV的产生。剂量为150,200和250μg/小鼠无效。刺激干扰素-β（IFN-Beta）生产仅在100和300μg/小鼠的剂量下观察，这解释了血清的中和能力。 IFN-GAMMA的量也与小鼠血清的抗病毒活性和中和活性良好。该药物几乎不会刺激IFN-Lambda的产生。因此，血清的中和活性和抗病毒活性主要由第1和第2 IFN基团决定。

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  • 来源
    《Biology Bulletin》 |2020年第5期|448-454|共7页
  • 作者

    Mishin D. V.; Isaeva E. I.; Grigorian S. S.; Balakina A. A.; Ilyichev A. V.; Deryabin P. G.; Maldov D. G.;

  • 作者单位

    Minist Hlth Russian Federat Ivanovskii Inst Virol Gamaleya Fed Res Ctr Epidemiol & Microbiol Fed State Budgetary Inst Moscow 123098 Russia;

    Minist Hlth Russian Federat Ivanovskii Inst Virol Gamaleya Fed Res Ctr Epidemiol & Microbiol Fed State Budgetary Inst Moscow 123098 Russia;

    Minist Hlth Russian Federat Gamalei Inst Epidemiol & Microbiol Gamaleya Fed Res Ctr Epidemiol & Microbiol Fed State Budgetary Inst Moscow 123098 Russia;

    Russian Acad Sci Fed State Budgetary Inst Inst Problems Chem Phys Moscow 142432 Moscow Oblast Russia;

    ZAO SKY Ltd Moscow 129301 Russia;

    Minist Hlth Russian Federat Ivanovskii Inst Virol Gamaleya Fed Res Ctr Epidemiol & Microbiol Fed State Budgetary Inst Moscow 123098 Russia;

    ZAO SKY Ltd Moscow 129301 Russia;

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