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Influence of vitamin D receptor haplotypes on blood lead concentrations in environmentally exposed children of Uygur and Han populations

机译：维吾尔族和汉族人群中维生素D受体单倍型对血铅浓度的影响

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摘要

Objective:To explore the association between polymorphism of vitamin D receptor (VDR) and lead poisoning in Uygur and Han children in China.rnMethods: The Bsml, Apal and Taql restriction sites of VDR genotyping were determined by polymerase chain reaction-restriction fragment length polymorphism in 443 Uygur and 469 Han children from Xinjiang province. The correlation between the polymorphism of VDR haplotypes and blood lead levels was explored.rnResults:The genotype frequencies of VDR had significant differences in Han and Uygur children (p <0.01). According to VDR-Bsml, Apal and Taql haplotype analysis in Han children, haplotypes Atb and AtB were considerably decreased in the lead poisoning group (p <0.05) while haplotype aTb and ATb were significantly increased in the lead poisoning group (p <0.01). However, such results were not found in Uygur children (p<0.05).rnConclusion: A significant difference was seen in the frequency distribution of the VDR genotype among the different races. Haplotypes Atb and AtB might be protective factors while haplotypes ATb and aTb might be risk factors in Han children.
机译：目的：探讨维吾尔族和汉族儿童维生素D受体（VDR）多态性与铅中毒之间的关系。方法：通过聚合酶链反应-限制性片段长度多态性测定VDR基因分型的Bsml，Apal和Taql限制性位点。来自新疆的443名维吾尔族和469名汉族儿童。结果：在汉族和维吾尔族儿童中，VDR的基因型频率存在显着差异（p <0.01）。根据VDR-Bsml，汉族儿童的Apal和Taql单倍型分析，铅中毒组单倍型Atb和AtB显着降低（p <0.05），铅中毒组单倍型aTb和ATb显着增加（p <0.01） 。然而，在维吾尔族儿童中未发现此类结果（p <0.05）。结论：不同种族之间VDR基因型的频率分布存在显着差异。 Atb和AtB单体型可能是保护性因素，而ATb和aTb单体型可能是汉族儿童的危险因素。

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  • 来源
    《Biomarkers》 |2010年第3期|P.232-237|共6页
  • 作者

    Yan Chen; rnJi-Wen Liu; rnJiang-Xia Zhao; rnJun Cui; rnWei Tian;

  • 作者单位

    Department of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, 830054, China;

    rnDepartment of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, China;

    rnSchool of Public Health, FuDan University, Shanghai, China;

    rnInsitute of Health Care for Children in Urumqi, Urumqi, Xinjiang, China;

    rnDepartment of Toxicology, School of Public Health, Xinjiang Medical University, Urumqi, Xinjiang, China;

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  • 正文语种 eng
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  • 关键词

    vitamin dreceptor; haplotype; lead poisoning; uygur; Han;

    机译：维生素D受体单倍型铅中毒;维吾尔族韩;

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