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Exploration of disease mechanism in acute kidney injury using a multiplex bead array assay: a nested case-control pilot study

机译：多重珠阵列检测探索急性肾脏损伤的疾病机制：病例对照研究

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摘要

Background: Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality.rnObjective. To evaluate the plasma profile of biomarkers potentially involved in AKI development following CPB.rnMethods: In a nested case-control study, plasma levels of 27 biomarkers in 11 AKI cases were compared with 25 controls.rnResults: Pre-CPB, plasma levels of epidermal growth factor and macrophage inflammatory protein-1β, 2 h following CPB, soluble vascular cell adhesion molecule-1 (sVCAM-1), fractalkine and macrophage inflammatory protein-1 a, and at later time points, sVCAM-1 and interleukin-6 were associated with AKI.rnConclusion: Biomarkers associated with AKI following CPB may merit further study.
机译：背景：经心脏体外循环（CPB）心脏手术后的急性肾损伤（AKI）会增加发病率和死亡率。方法：在一项巢式病例对照研究中，将11例AKI病例中27种生物标志物的血浆水平与25例对照进行了比较.rn结果：CPB前，表皮血浆水平CPB，可溶性血管细胞黏附分子-1（sVCAM-1），分数链烷烃和巨噬细胞炎性蛋白-1a在CPB后2 h产生了生长因子和巨噬细胞炎性蛋白1β，在随后的时间点分别是sVCAM-1和白介素-6结论：CPB后与AKI相关的生物标志物值得进一步研究。

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  • 来源
    《Biomarkers》 |2010年第5期|P.436-445|共10页
  • 作者

    Orfeas Liangos; Francesco Addabbo; Hocine Tighiouart; Michael Goligorsky; Bertrand L. Jaber;

  • 作者单位

    Kidney & Dialysis Research Laboratory, St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA Division of Nephrology, Klinikum Coburg, Coburg, Germany III. Med. Klinik, Klinikum Coburg, Ketschendorfer Str. 33, 96450 Coburg, Germany;

    rnFaculty of Medicine and Surgery, Department of Pharmacology and Human Physiology, Universita degli Studi di Bari, Italy;

    rnBiostatistics Research Center, Tufts Medical Center, Boston, MA, USA;

    rnDivision ofNephrology, New York Medical College, Valhalla, NY, USA;

    rnKidney & Dialysis Research Laboratory, St Elizabeth's Medical Center, Tufts University School of Medicine, Boston, MA, USA;

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  • 正文语种 eng
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  • 关键词

    cardiac surgery; cardiopulmonary bypass; acute renal failure; pathophysiology; biomarker;

    机译：心脏手术;心肺旁路急性肾功能衰竭;病理生理学生物标志物;

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