...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Biomarkers >Serum interleukin-1β as a marker for differentiation of asthma and chronic obstructive pulmonary disease
【24h】

Serum interleukin-1β as a marker for differentiation of asthma and chronic obstructive pulmonary disease

机译：血清白介素-1β可作为哮喘和慢性阻塞性肺疾病鉴别的标志物

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Asthma and chronic obstructive pulmonary disease (COPD) are diseases of airway inflammation with clinical and physiological similarities, making their differentiation difficult. Airway inflammatory changes are associated with systemic changes. However, no serum marker is known for their differentiation. Therefore, serum interleukin (IL)-1β levels were determined. Out of a total of 1023 patients screened, we included in the study ten patients each with atopic asthma, non-atopic asthma and COPD and ten healthy subjects. Skin prick tests with 14 inhalant allergens were performed on each patient. Blood was collected in the symptomatic and asymptomatic phases of the diseases and serum IL-1β and IgE levels were determined. Our results showed that in the symptomatic phase in asthmatics, serum IL-1β levels were higher (P<0.05) than in patients with COPD. Serum IgE levels were higher (P<0.05) in atopic asthmatics than in non-atopic asthmatics and in COPD patients. We conclude that serum IL-1β level determination during the symptomatic phase of the diseases may help to differentiate asthmatics from patients with COPD. Serum IgE levels may differentiate atopic asthmatics from non-atopic asthmatics and COPD patients.
机译：哮喘和慢性阻塞性肺疾病（COPD）是具有临床和生理相似性的气道炎症疾病，因此很难区分。气道炎症变化与全身变化有关。但是，尚无血清标记物可区分它们。因此，确定了血清白介素（IL）-1β水平。在总共筛选的1023名患者中，我们在研究中纳入了10名每位患有特应性哮喘，非特应性哮喘和COPD的患者以及10名健康受试者。对每位患者进行了14种吸入性过敏原的皮肤点刺试验。在疾病的症状期和无症状期收集血液，并测定血清IL-1β和IgE水平。我们的结果表明，在哮喘患者的症状期，血清IL-1β水平高于COPD患者（P <0.05）。特应性哮喘患者的血清IgE水平高于非特应性哮喘患者和COPD患者（P <0.05）。我们得出结论，在疾病的症状期测定血清IL-1β水平可能有助于将哮喘患者与COPD患者区分开。血清IgE水平可将特应性哮喘与非特应性哮喘和COPD患者区分开。

著录项

  • 来源
    《Biomarkers》 |2008年第8期|713-727|共15页
  • 作者

    BHAWNA MAHAJAN; VANNAN KANDI VIJAYAN; MAHENDRA KUMAR AGARWAL; SURENDRA KUMAR BANSAL;

  • 作者单位

    Departments of Biochemistry, V. P. Chest Institute, University of Delhi, Delhi, 110007, India;

    Departments of Respiratory Medicine, V. P. Chest Institute, University of Delhi, Delhi, 110007, India;

    Departments of Respiratory Allergy and Applied Immunology, V. P. Chest Institute, University of Delhi, Delhi, 110007, India;

    Departments of Biochemistry, V. P. Chest Institute, University of Delhi, Delhi, 110007, India;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    diagnostic techniques; respiratory tract diseases; cytokines;

    机译：诊断技术;呼吸道疾病;细胞因子;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号