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Optimization of microbubble side-scattering signal analysis for efficient cavitation dosimetry

机译：微泡侧散射信号分析优化高效空化剂量分析

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摘要

In this study microbubble (MB) cavitation signal analysis was performed in both pressure and exposure duration domains of the acoustic field with the aim to optimize current cavitation dosimetry model by the application of signal processing. The discrete wavelet transform is applied to denoise the non-stationary US signals. For the development of universal cavitation dosimetry model and unification of cavitation dosimetry protocols, we have defined the optimal frequency range to be associated with the highest values of differential inertial cavitation dose (ICD). At our experimental conditions, it was evaluated to be 1.5-1.8 MHz, as ICD, quantified in this frequency band, is clearly distinguished from ICD of other frequency ranges. The explicitly high RMS values, obtained in 1.5-1.8 MHz frequency range, not only allow to track MB dynamics with the highest accuracy but also perform sonoporation optimization in exposure duration scale by RMS decrease to the background level. For sonoporation temporal dosimetry we have introduced "MB survival time" the estimate, based on system output characteristics and directly related to sonoporation outcome. The rate of "MB survival time" has high correlation (R = 0.85, p 0.05) with pre-existing index, ICD, and therefore, implies a possibility to be used for dosimetric applications for US-mediated drug and gene delivery. The rate of "MB survival time" is a time-dependent measure, which implies universal result reproducibility, as it is possible to relate absolute values of time dependent indexes to particular in vitro/in vivo bioeffects.
机译：在该研究中，在声场的压力和曝光持续时间域中进行微泡（MB）空化信号分析，目的是通过应用信号处理来优化电流空化剂量测定模型。将离散小波变换应用于不静止的美国信号。为了开发通用空化剂量模型和空化剂量法协议的统一，我们已经确定了与差分惯性空化剂量（ICD）的最高值相关的最佳频率范围。在我们的实验条件下，它被评估为1.5-1.8 MHz，因为在该频段中量化的ICD，与其他频率范围的ICD明确区分。在1.5-1.8MHz的频率范围内获得明确的高RMS值，不仅允许以最高精度跟踪MB动态，而且通过RMS减少到背景级别，在曝光持续时间刻度下执行声载优化。对于持仓时间剂量测定法，我们已经引入了“MB生存时间”估计，基于系统输出特性，直接与声频结果直接相关。 “MB存活时间”的速率具有高相关（R = 0.85，P <0.05），预先存在指数，ICD，因此，可以用于用于美国介导的药物和基因递送的剂量测定应用。 “MB生存时间”的速率是一种时间依赖的措施，其意味着通用的结果再现性，因为它可以将时间依赖性指标的绝对值与特定的体内/体内生物效应相关。

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  • 来源
    《Biomedical signal processing and control》 |2021年第1期|102235.1-102235.10|共10页
  • 作者

    Maciulevicius Martynas; Tiwari Kumar Anubhav; Navickaite Diana; Chopra Sonam; Satkauskas Saulius; Raisutis Renaldas;

  • 作者单位

    Vytautas Magnus Univ Fac Nat Sci Biophys Res Grp Vileikos St 8 LT-44404 Kaunas Lithuania;

    Kaunas Univ Technol Prof K Barsauskas Ultrasound Res Inst K Barsausko St 59 LT-51423 Kaunas Lithuania|Kaunas Univ Technol Dept Multimedia Engn Studentu St 50 LT-51368 Kaunas Lithuania;

    Vytautas Magnus Univ Fac Nat Sci Biophys Res Grp Vileikos St 8 LT-44404 Kaunas Lithuania;

    Vytautas Magnus Univ Fac Nat Sci Biophys Res Grp Vileikos St 8 LT-44404 Kaunas Lithuania;

    Vytautas Magnus Univ Fac Nat Sci Biophys Res Grp Vileikos St 8 LT-44404 Kaunas Lithuania;

    Kaunas Univ Technol Prof K Barsauskas Ultrasound Res Inst K Barsausko St 59 LT-51423 Kaunas Lithuania|Kaunas Univ Technol Fac Elect & Elect Engn Dept Elect Power Syst Studentu G48 LT-51367 Kaunas Lithuania;

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  • 正文语种 eng
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  • 关键词

    Ultrasound; Side-scattering; Wavelet; Microbubbles; Sonoporation;

    机译：超声波;侧散射;小波;微泡;声孔;

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