Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: A new class of antiviral acyclic nucleoside phosphonates

Hyunah Choo; James R. Beadle; Youhoon Chong; Julissa Trahan; Karl Y. Hostetler

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Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: A new class of antiviral acyclic nucleoside phosphonates

机译：5-膦酰基-戊-2-烯-1-基核苷的合成：一类新的抗病毒无环核苷膦酸酯

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A new class of acyclic nucleoside phosphonates, the 5-phosphono-pent-2-en-1-yl nucleosides and their hexadecyloxypro-pyl esters, were synthesized from butyn-1-ol. Only the hexadecyloxypropyl esters showed antiviral activity against herpes simplex virus type 1, in vitro. Hexadecyloxypropyl 1-(5-phosphono-pent-2-en-1-yl)-thymine was the most active and selective compound among the synthesized nucleotides with an EC_(50) value of 0.90 μM.

机译：由丁炔-1-醇合成了一类新型的无环核苷膦酸酯，即5-膦酰基-戊-2-烯-1-基核苷及其十六烷基氧基丙基酯。在体外，仅十六烷氧基丙基酯显示出对1型单纯疱疹病毒的抗病毒活性。十六烷基氧丙基1-（5-膦酰基-戊-2-烯-1-基）-胸腺嘧啶是合成核苷酸中最具活性和选择性的化合物，EC_（50）值为0.90μM。

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《Bioorganic and Medicinal Chemistry》 |2007年第4期|1771-1779|共9页
作者
Hyunah Choo; James R. Beadle; Youhoon Chong; Julissa Trahan; Karl Y. Hostetler;
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作者单位

Department of Medicine, Division of Infectious Disease, University of California, San Diego, La Jolla, CA 92093-0676, USA;

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原文格式 PDF
正文语种 eng
中图分类药学;生物化学;
关键词
antivirals; nucleosides; nucleoside phosphonates; prodrugs;

机译：抗病毒药核苷;核苷膦酸酯;前药;

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1. Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: a new class of antiviral acyclic nucleoside phosphonates. [J] . Choo H, Beadle JR, Chong Y, Bioorganic and medicinal chemistry . 2007,第4期

机译：5-膦酰基-戊-2-烯-1-基核苷的合成：一类新的抗病毒无环核苷膦酸酯。
2. Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: a new class of antiviral acyclic nucleoside phosphonates. [J] . ChooH, BeadleJR, ChongY, Bioorganic and Medicinal Chemistry . 2007,第4期

机译：5-膦酰基-戊-2-烯-1-基核苷的合成：一类新的抗病毒无环核苷膦酸酯。
3. Synthesis of the 5-phosphono-pent-2-en-l-yl nucleosides: A new class of antiviral acyclic nucleoside phosphonates [J] . Hyunah Choo, James R. Beadle, Youhoon Chong, Bioorganic and Medicinal Chemistry . 2007,第4期

机译：5-膦酰基-戊-2-烯-1-基核苷的合成：一类新的抗病毒无环核苷膦酸酯
4. Acyclic nucleoside phosphonates as a new class of anti-malarial compounds: Inhibition of Plasmodium falciparum hypoxanthine-guahine-xanthine phosphoribosyltransferase by 9-2-(2-phosphonoethoxy)ethyl-purines and their branched derivatives [C] . Dana Hockova, Antonin Holy, Dianne T. Keough European Symposium on Organic Chemistry . 2009

机译：环状核苷膦酸盐作为一种新的抗疟疾化合物：抑制疟原虫脱氧黄嘌呤 - 黄嘌呤 - 黄嘌呤磷酰基转移酶的抑制作用9- 2-（2-膦酰基乙氧基）乙基 - 杂物和其支化衍生物
5. The Design, Synthesis, and Biological Evaluation of a Series of Acyclic Fleximer Nucleoside Antivirals. [D] . Peters, Hannah Louise. 2015

机译：一系列无环Fleximer核苷抗病毒药的设计，合成和生物学评估。
6. Synthesis of the 5-Phosphonopent-2-en-1-yl Nucleosides: A New Class of Antiviral Acyclic Nucleoside Phosphonates [O] . Hyunah Choo, James R. Beadle, Youhoon Chong, -1

机译：5-Phosphonopent-2-en-1-yl核苷的合成：一类新型的抗病毒无环核苷膦酸酯。
7. Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: A new class of antiviral acyclic nucleoside phosphonates [O] . Hyunah Choo, James R. Beadle, Youhoon Chong, 2007

机译：5-膦酰氯-2-烯-1-基核苷的合成：一类新的抗病毒无环核苷膦酸盐
8. Synthesis of Nucleoside Analogues with Potential Antiviral Activity against Negative Strand RNA Virus Targets. [R] . Walker, R. T. 1989

机译：具有抗负链RNa病毒靶标的潜在抗病毒活性的核苷类似物的合成。

Synthesis of the 5-phosphono-pent-2-en-1-yl nucleosides: A new class of antiviral acyclic nucleoside phosphonates

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