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首页> 外文期刊>Bioorganic and Medicinal Chemistry >Antidepressant-like profile of action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo (a,d) cycloheptane in mice evaluated in the forced swimming test.
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Antidepressant-like profile of action of two 4-amine derivatives of 10,11-dihydro-5H-dibenzo (a,d) cycloheptane in mice evaluated in the forced swimming test.

机译：在强迫游泳试验中评估的10,11-二氢-5H-二苯并（a，d）环庚烷的两种4-胺衍生物在小鼠中的抗抑郁样作用概况。

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摘要

This study investigated the antidepressant-like effect of 4-amine derivatives of 10,11-dihydro-5H-dibenzo-alkylamine-cycloheptane, 4-amine (3-N,N-dimethylpropylamine)-10,11-dihydro-5H-dibenzo[a,d]cycloheptane-5-on e (ADDCH1) and 1,2,3,4,8,9-hexahydro-dibenzocyclohepta[4,4a,5-ef]1,4-diazepin (ADDCH2), in a validated experimental model of depression, the forced swimming test (FST) in mice. Female adult mice were sub-chronically (three doses in 24 h) or repeatedly (once a day for 10 days) treated with either of the compounds and evaluated in the FST. The sub-chronic treatment promoted a dose-dependent reduction in the immobility time in the FST with the doses of 50 mg/kg (ADDCH1) and 30 mg/kg (ADDCH2) ip being the most effective (33% and 37% of reduction, respectively). A similar profile of action was observed in the animals repeatedly treated with ADDCH1 50 mg/kg or ADDCH2 30 mg/kg ip (for 10 days) and there was no sign of motor impairment or locomotor activation as evaluated in the rota-rod and open-field tests, respectively. These findings suggest that these amine derivatives of the system dibenzocycloheptane have an antidepressant-like action which could be of clinical interest and, therefore, deserves further investigation. In addition, putative underlying mechanisms of action are discussed.
机译：这项研究调查了10,11-二氢-5H-二苯并烷基胺-环庚烷，4-胺（3-N，N-二甲基丙胺）-10,11-二氢-5H-二苯并烷的4-胺衍生物的抗抑郁作用[a，d]环庚烷5-on e（ADDCH1）和1,2,3,4,8,9-六氢-二苯并环庚[4,4a，5-ef] 1,4-二氮杂（ADDCH2）经过验证的抑郁症实验模型，小鼠的强迫游泳试验（FST）。用两种化合物中的任一种对亚成年雌性小鼠进行亚慢性（24小时内三剂）或重复（一天一次，共10天）治疗，并在FST中进行评估。亚慢性治疗促进了FST固定时间的剂量依赖性减少，其中50 mg / kg（ADDCH1）和30 mg / kg（ADDCH2）ip的剂量最为有效（减少量分别为33％和37％） ， 分别）。在重复用ADDCH1 50 mg / kg或ADDCH2 30 mg / kg ip ip（持续10天）反复治疗的动物中观察到了相似的作用曲线，并且在旋转棒和开放状态中没有运动障碍或运动激活的迹象现场测试。这些发现表明，二苯并环庚烷体系的这些胺衍生物具有类抗抑郁药的作用，可能具有临床意义，因此值得进一步研究。此外，讨论了假定的潜在作用机理。

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