Effect of photosensitizers pheophorbide a and protoporphyrin IX on skin wound healing upon low-intensity laser irradiation

E A Lyapina T V Machneva E A Larkina E P Tkachevskaya A N Osipov A F Mironov

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Effect of photosensitizers pheophorbide a and protoporphyrin IX on skin wound healing upon low-intensity laser irradiation

机译：光敏剂脱镁叶绿酸a和原卟啉IX对低强度激光照射下皮肤伤口愈合的影响

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The effect of photosensitizer with subsequent He-Ne (632.8 nm; 3 mW/cm^sup 2^) laser irradiation on experimental skin wound healing has been studied. Pheophorbide a and protoporphyrin IX were used as photosensitizers. It was found that application of the photosensitizer and subsequent laser irradiation, first, decreased the amount and the functional activity of leukocytes in the wound exudate and, second, inhibited the SOD activity as compared with that of the control group. Moreover, pheophorbide and protoporphyrin practically did not affect the total healing period but decreased the length of the inflammation stage. It was supposed that these effects are related to generation of reactive oxygen species during irradiation.[PUBLICATION ABSTRACT]

机译：研究了光敏剂和随后的He-Ne（632.8 nm; 3 mW / cm ^ sup 2 ^）激光照射对实验性皮肤伤口愈合的影响。荧光素a和原卟啉IX被用作光敏剂。已经发现，与对照组相比，光敏剂的施用和随后的激光照射首先降低了伤口渗出液中白细胞的数量和功能活性，其次抑制了SOD活性。而且，脱镁叶绿酸和原卟啉实际上不影响总的治愈期，但是减少了炎症期的长度。据推测，这些影响与照射过程中活性氧的产生有关。[摘要]

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《Biophysics》 |2010年第2期|p.1-6|共6页
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E A Lyapina T V Machneva E A Larkina E P Tkachevskaya A N Osipov A F Mironov;
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1. Effect of Photosensitizers Pheophorbide a and Protoporphyrin IXon Skin Wound Healing upon Low-intensity Laser Irradiation [J] . E. A. Lyapina, T. V. Machneva, E. A. Larkina, Biophysics . 2010,第2期

机译：光敏剂荧光素a和原卟啉IX对低强度激光照射皮肤伤口愈合的影响
2. The effect of low-intensity laser irradiation in the blue, green, and red spectral ranges on healing of experimental skin wounds in rats [J] . T. V. Machneva, D. M. Protopopov, Yu. A. Vladimirov, Biophysics . 2008,第5期

机译：蓝色，绿色和红色光谱范围内的低强度激光照射对大鼠实验性皮肤伤口愈合的影响
3. Efficacy of Ultraviolet Radiation-C (254 nm) and Low-Intensity Laser in the Healing of Wounds in Irradiated Skin [J] . Rajani V. Kanade, D.K. Vijaykumar, Thomas Cherian, Hong Kong Physiotherapy Journal . 2002,第1期

机译：紫外线-C（254 nm）和低强度激光在照射皮肤伤口愈合中的功效
4. Effect of low-intensity He-Ne laser irradiation in healing process of skin-scalded wounds in rats [C] . Zhuwen Liu, Capital Univ. of Medical Sciences, Beijing, Biomedical Optics and Lasers: Diagnostics and Treatment . 1998

机译：低强度氦氖激光辐照对大鼠皮肤烫伤创面愈合的影响
5. Immunomodulatory effects of the endogenously synthesized photosensitizer, protoporphyrin IX. [D] . Hryhorenko, Eric Andrew. 1998

机译：内源性合成光敏剂原卟啉IX的免疫调节作用。
6. Effects of low intensity laser irradiation during healing of infected skin wounds in the rat [O] . Ethne L. Nussbaum, Facundo Las Heras, Kenneth P.H. Pritzker, -1

机译：低强度激光照射在大鼠皮肤感染伤口愈合中的作用
7. Efficacy of Ultraviolet Radiation-C (254 nm) and Low-Intensity Laser in the Healing of Wounds in Irradiated Skin [O] . Kanade Rajani V., Vijaykumar D.K., Cherian Thomas, 2002

机译：紫外线C（254 nm）和低强度激光在照射皮肤伤口愈合中的功效
8. Efficacy of Laser Debridement With Autologous Split-Thickness Skin Grafting in Promoting Improved Wound Healing of Deep Cutaneous Sulfur Mustard Burns [R] . Graham, J. S. , Zchomacker, K. T. , Glatter, R. D. , 2002

机译：激光清创自体分层厚度皮肤移植促进深层皮肤硫芥烧伤创面愈合的疗效

Effect of photosensitizers pheophorbide a and protoporphyrin IX on skin wound healing upon low-intensity laser irradiation

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