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Quantitative analysis of hydrogen peroxide with special emphasis on biosensors

机译：过氧化氢的定量分析，特别是生物传感器

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Determination of hydrogen peroxide (H2O2) has become essential in pharmaceutical, biological, clinical and environmental studies. The conventional detection methods of H2O2 such as colourimetry, titration, chromatography, spectrophotometry, fluorimetry, chemiluminescence have limited success, due to their poor selectivity and sensitivity, long analysis time and lack of long-term reliability and reproducibility. The biosensors overcome these limitations because of their simplicity, rapidity, selectivity and high sensitivity. This review describes the principle, analytic parameters, merits and demerits of various methods of H2O2 determination with special emphasis on biosensors. The classification of biosensors based on various materialsanomaterials and electrodes have been described in detail. The recent advances in vivo sensing and bio-sensing of H2O2 by hemoglobin nanoparticles are also presented. The significant challenges and future perspective for highly selective H2O2 detection are discussed.
机译：在制药，生物，临床和环境研究中，过氧化氢（H2O2）的测定已变得至关重要。 H2O2的常规检测方法，如比色法，滴定法，色谱法，分光光度法，荧光法，化学发光法，由于其选择性和灵敏度较差，分析时间长且缺乏长期可靠性和可重复性而取得的成功有限。生物传感器由于其简单，快速，选择性和高灵敏度而克服了这些限制。这篇综述描述了各种H2O2测定方法的原理，分析参数，优缺点，特别着重于生物传感器。已经详细描述了基于各种材料/纳米材料和电极的生物传感器的分类。还介绍了血红蛋白纳米粒子对H2O2的体内感测和生物感测的最新进展。讨论了高选择性H2O2检测的重大挑战和未来前景。

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