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Graphene nanoflakes on transparent glass electrode sensor for electrochemical sensing of anti-diabetic drug

机译:透明玻璃电极传感器上的石墨烯纳米薄片用于抗糖尿病药物的电化学传感

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Metformin (Mf) plays a major role in controlling insulin level of individuals at risk of developing diabetes mellitus. Overdose of Mf can cause lactic acidosis, diarrhoea, cough, or hoarseness, etc. These particulars point out the identification for selective and sensitive methods of Mf determination. In the present work, graphene nanoflakes-polymethylene blue (GNF-PMB) nano-composites were developed onto fluorine-doped tin oxide (SnO2/F) coated glass substrates for electrochemical sensing of Mf using cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The developed sensor shows quick response time (10 s), linearity as 10-10(3) A mu M, LOD (0.1 nM), and good shelf life (10 weeks). Attempts have been made to utilize this electrode for estimation of Mf in urine samples. Configured as a highly responsive, reproducible Mf sensor, it combines the electrical properties of GNF and stable electron transfer of PMB. The newly developed Mf sensor presents a promising candidate in point-of-care diagnosis.
机译:二甲双胍(Mf)在控制有患糖尿病风险的个体的胰岛素水平中起主要作用。过量的Mf会导致乳酸性酸中毒,腹泻,咳嗽或声音嘶哑等。这些细节指出了对Mf测定的选择性和灵敏方法的鉴定。在当前的工作中,将石墨烯纳米薄片-聚亚甲基蓝(GNF-PMB)纳米复合材料开发到氟掺杂的氧化锡(SnO2 / F)涂覆的玻璃基板上,以使用循环伏安法(CV)和电化学阻抗光谱法对Mf进行电化学感测( EIS)。开发的传感器显示出快速的响应时间(10 s),线性为10-10(3)A M M,LOD(0.1 nM)和良好的保质期(10周)。已经尝试使用该电极来估计尿液样品中的Mf。配置为高响应性,可重现的Mf传感器,它结合了GNF的电特性和PMB的稳定电子传递。新开发的Mf传感器为即时诊断提供了有希望的候选者。

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