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Bioconversion of piceid to resveratrol by selected probiotic cell extracts

机译：通过选择的益生菌细胞提取物将木脂苷生物转化为白藜芦醇

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Resveratrol exerts several pharmacological activities, including anti-cancer, anti-inflammatory, cardioprotective, or antioxidant effects. However, due to its occurrence in plants more in glycosidic form as piceid, the bioavailability and bioactivity are limited. The enzymatic potential of probiotics for the transformation of piceid to resveratrol was elucidated. Cell extract from Bifidobacteria (B.) infantis, B. bifidum, Lactobacillus (L.) casei, L. plantarum, and L. acidophilus was evaluated for their effect in this bioconversion using high-performance liquid chromatography (HPLC) as analytical tool. Cell extract of B. infantis showed the highest effect on the deglycosylation of piceid to resveratrol, already after 30 min. Cell extracts of all other tested strains showed a significant biotransformation with no further metabolization of resveratrol. The conversion of piceid to resveratrol is of importance to increase bioavailability and bioactivity as shown for anti-inflammation in this study. Cell extracts from probiotics, especially from B. infantis, may be added to piceid containing products, for achieving higher biological effects caused by the bioactivity of resveratrol or by health promoting of the probiotics. These findings open a new perspective of novel combination of cell extracts from probiotics and piceid, in health-promoting pharmaceutical and food products.
机译：白藜芦醇具有多种药理活性，包括抗癌，抗炎，心脏保护或抗氧化作用。但是，由于其在植物中以糖苷形式（如木偶）存在，因此其生物利用度和生物活性受到限制。阐明了益生菌的酶促潜力，可以将木脂苷转化为白藜芦醇。使用高效液相色谱（HPLC）作为分析工具，评估了婴儿双歧杆菌，双歧杆菌，干酪乳杆菌，植物乳杆菌和嗜酸乳杆菌的细胞提取物在此生物转化中的作用。婴儿双歧杆菌的细胞提取物在30分钟后就已显示出对木脂苷去糖基化为白藜芦醇的最大作用。所有其他测试菌株的细胞提取物均显示出明显的生物转化，没有白藜芦醇的进一步代谢。如本研究中所显示的，将木脂苷转化为白藜芦醇对于提高生物利用度和生物活性具有重要意义。可以将来自益生菌，特别是来自婴儿双歧杆菌的细胞提取物添加到含糊精的产品中，以实现由白藜芦醇的生物活性或益生菌的健康促进所引起的更高的生物学作用。这些发现为促进健康的药品和食品中的益生菌和糊精的细胞提取物的新颖组合开辟了新的前景。

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