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首页> 外文期刊>BMC Clinical Pathology >The co-expression of functional gastric proteins in dynamic gastric diseases and its clinical significance
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The co-expression of functional gastric proteins in dynamic gastric diseases and its clinical significance

机译:功能性胃蛋白在动态胃病中的共表达及其临床意义

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Background Pepsinogen C (PGC) and mucin1 (MUC1) are important physiologically functional gastric proteins; Mucin2 (MUC2) is an “ectopic” functional protein in intestinal metaplasia of gastric mucosa. We analyzed the co-expression of the above-mentioned three proteins in dynamic gastric diseases {superficial gastritis (SG)-atrophic gastritis (AG)--gastric cancer (GC)} as well as different histological types of gastric cancer in order to find molecular phenotypes of gastric cancer and precancerous disease and further explore the potential co-function of PGC, MUC1 and MUC2 in the occurrence and development of gastric cancer.
机译:背景胃蛋白酶原C(PGC)和粘蛋白1(MUC1)是重要的生理功能胃蛋白;因此,胃蛋白酶具有重要的生理意义。 Mucin2(MUC2)是胃黏膜肠上皮化生中的“异位”功能蛋白。我们分析了上述三种蛋白质在动态胃部疾病{浅表性胃炎(SG)-萎缩性胃炎(AG)-胃癌(GC)}以及胃癌的不同组织学类型中的共表达,以发现胃癌和癌前疾病的分子表型,并进一步探索PGC,MUC1和MUC2在胃癌发生和发展中的潜在作用。

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